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Titolo:
GLYCEMIA-LOWERING EFFECT OF COBALT CHLORIDE IN THE DIABETIC RAT - INCREASED GLUT1 MESSENGER-RNA EXPRESSION
Autore:
YBARRA J; BEHROOZ A; GABRIEL A; KOSEOGLU MH; ISMAILBEIGI F;
Indirizzi:
CASE WESTERN RESERVE UNIV,DEPT MED CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT MED CLEVELAND OH 44106
Titolo Testata:
Molecular and cellular endocrinology
fascicolo: 2, volume: 133, anno: 1997,
pagine: 151 - 160
SICI:
0303-7207(1997)133:2<151:GEOCCI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOSE TRANSPORTER EXPRESSION; SKELETAL-MUSCLE; CLONE-9 CELLS; INSULIN; PROTEIN; INHIBITION; HOMEOSTASIS; STIMULATION; METABOLISM; GLUCAGON;
Keywords:
INSULIN; GLUCAGON; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (GAPDH) MESSENGER-RNA; STREPTOZOTOCIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
J. Ybarra et al., "GLYCEMIA-LOWERING EFFECT OF COBALT CHLORIDE IN THE DIABETIC RAT - INCREASED GLUT1 MESSENGER-RNA EXPRESSION", Molecular and cellular endocrinology, 133(2), 1997, pp. 151-160

Abstract

We have recently shown that expression of the GLUT1 glucose transporter isoform is augmented in cells exposed to cobalt chloride [Co(II)], an agent that stimulates the expression of hyposia-responsive genes (Behrooz, A., Ismail-Beigi, F., 1997. J. Biol. Chem. 272, 5555-5562.). Here, we examine the effect of Co(II) on glycemia and tissue GLUT1 mRNAcontent of normal and diabetic rats. The addition of 2 mM Co(II) in the drinking water reduced the glycemia of streptozotocin-induced diabetic rats by day 3 from 32.3 +/- 2.1 to 21.0 +/- 1.9 mM (non-fasting). Co(II) resulted in no change in serum insulin levels of normal or diabetic rats. Treatment with 4 mM Co(II) was more effective than 2 mM Co(II) in reducing the glycemia of diabetic rats, while 6 mM Co(II) was associated with severe toxicity. GLUT1 mRNA content increased significantly in ventricular myocardium, renal cortex, skeletal muscle, cerebrum and liver of normal and diabetic rats treated with 2 mM cobalt chloride (ranging from 1.3- to 2.9-fold in the different tissues). It is concluded that: (1) treatment with Co(II) decreases the glycemia of diabetic rats, and (2) the glycemia-lowering effect of Co(II) is associated with, and may be mediated by, enhanced expression of GLUT1 mRNA. (C)1997 Elsevier Science Ireland Ltd.

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Documento generato il 21/09/20 alle ore 16:14:18