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Titolo:
FLUCONAZOLE-RESISTANT CANDIDA SPECIES FRO M HIV-INFECTED PATIENTS WITH RECURRENT CANDIDA-STOMATITIS - CROSSRESISTANCE TO ITRACONAZOLE AND KETOCONAZOLE
Autore:
METZGER S; HOFMANN H;
Indirizzi:
TECH UNIV MUNICH,KLIN & POLIKLIN DERMATOL & ALLERGOL BIEDERSTEIN,BIEDERSTEINERSTR 29 D-80802 MUNICH GERMANY TECH UNIV MUNICH,KLIN & POLIKLIN DERMATOL & ALLERGOL BIEDERSTEIN D-80802 MUNICH GERMANY
Titolo Testata:
Mycoses
, volume: 40, anno: 1997, supplemento:, 1
pagine: 56 - 63
SICI:
0933-7407(1997)40:<56:FCSFMH>2.0.ZU;2-0
Fonte:
ISI
Lingua:
GER
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; ANTIFUNGAL SUSCEPTIBILITY TEST; BROTH MACRODILUTION; ALBICANS STRAINS; OROPHARYNGEAL CANDIDIASIS; AZOLE RESISTANCE; AIDS; MICRODILUTION; THERAPY; YEASTS;
Keywords:
CANDIDA; FLUCONAZOLE; ITRACONAZOLE; KETOCONAZOLE; SUSCEPTIBILITY TESTING; HIV INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
S. Metzger e H. Hofmann, "FLUCONAZOLE-RESISTANT CANDIDA SPECIES FRO M HIV-INFECTED PATIENTS WITH RECURRENT CANDIDA-STOMATITIS - CROSSRESISTANCE TO ITRACONAZOLE AND KETOCONAZOLE", Mycoses, 40, 1997, pp. 56-63

Abstract

In vitro susceptibility to fluconazole of Candida species isolated from 83 HIV-infected patients treated with fluconazole because of recurrent Candida stomatitis was monitored over a period of two years. A microdilution assay with high-resolution antifungal assay (HR) medium andRPMI 1640-medium were compared. In vitro less susceptible and fluconazole resistant C. species were observed in 23 patient at the end of the study. The Candida isolates recovered from oral rinsing fluids at the beginning and the end of study were tested for crossresistance to itraconazole and ketoconazole. Susceptibility to ketoconazole and to itraconazole was reduced using RPMI 1640-medium. Susceptibility of the isolates to fluconazole was not influenced by the assay medium. In 21 patients in vitro fluconazole resistant or less susceptible C. albicans were observed. 9 of 21 isolates showed crossresistance to itroconazoleand ketoconazole. in 10 isolates only crossresistance to itraconazolewas observed. During fluconazole treatment double infections due to combination of C. albicans and C. glabrata or C. krusei increased from 20% to 78%. C. krusei was resistant to the three azoles. C. glabrata was less susceptible (4-8 mg/l) or resistant (>8 mg/l) to fluconazole and resistant to itraconazole and ketoconazole. High dosed intravenous fluconazole treatment with 400 to 600 mg daily failed in 11 patients with fluconazole resistant C. albicans and in 3 (3/10) patients with les susceptible C. albicans isolates.

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Documento generato il 05/12/20 alle ore 10:08:03