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Titolo:
COPPER-METALLOTHIONEIN IN THE KIDNEY OF MACULAR MICE - A MODEL FOR MENKES-DISEASE
Autore:
SUZUKIKURASAKI M; OKABE M; KURASAKI M;
Indirizzi:
HOKKAIDO UNIV,GRAD SCH ENVIRONM EARTH SCI,DEPT ENVIRONM MED & INFORMAT,KITA KU,KITA 10 NISHI 5 SAPPORO HOKKAIDO 060 JAPAN HOKKAIDO UNIV,GRAD SCH ENVIRONM EARTH SCI,DEPT ENVIRONM MED & INFORMAT,KITA KU SAPPORO HOKKAIDO 060 JAPAN
Titolo Testata:
The Journal of histochemistry and cytochemistry
fascicolo: 11, volume: 45, anno: 1997,
pagine: 1493 - 1501
SICI:
0022-1554(1997)45:11<1493:CITKOM>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVANS CINNAMON RATS; MOTTLED MOUSE MUTANTS; KINKY-HAIR SYNDROME; BRINDLED MOBR MICE; CANDIDATE GENE; LEC RATS; CADMIUM-METALLOTHIONEIN; HEREDITARY HEPATITIS; BINDING-PROTEIN; WILSONS-DISEASE;
Keywords:
COPPER; METALLOTHIONEIN; MENKES DISEASE; MACULAR MOUSE; KIDNEY; IN SITU BLOTTING; AUTOFLUORESCENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
M. Suzukikurasaki et al., "COPPER-METALLOTHIONEIN IN THE KIDNEY OF MACULAR MICE - A MODEL FOR MENKES-DISEASE", The Journal of histochemistry and cytochemistry, 45(11), 1997, pp. 1493-1501

Abstract

Menkes disease is an X-linked disorder of copper metabolism. Excess amounts of copper in the kidney of Macular mice, a model for this disease, were found as copper-metallothionein (Cu-MT) from kidney of the mice. Histochemical studies of Cu-MT based on its autofluorescent emission properties showed that the protein was predominant in the proximal convoluted tubule (PCT) cells of the cortex. PCT cells are known to bethe primary site of the nephrotoxicity caused by heavy metals. MT mRNA was also observed in the cortex, indicating that the protein was biosynthesized in this region. On the basis of these results, we suggest that biosynthesis and degradation of Cu-MT occur repeatedly in the PCTcells of the cortex. We also compared the histochemical localization of Cu-MT in Macular mice and Long-Evans cinnamon rats, a model for Wilson's disease. The significance of this comparison is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:01:38