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Titolo:
CHANGES IN REGIONAL CEREBRAL BLOOD-FLOW FOLLOWING LIGHT TREATMENT FORSEASONAL AFFECTIVE-DISORDER - RESPONDERS VERSUS NONRESPONDERS
Autore:
VASILE RG; SACHS G; ANDERSON JL; LAFER B; MATTHEWS E; HILL T;
Indirizzi:
NEW ENGLAND DEACONESS HOSP,DEPT PSYCHIAT,PALMER BAKER SPAN 4,1 DEACONESS RD BOSTON MA 02215 HARVARD UNIV,SCH MED,DEPT PSYCHIAT BOSTON MA 02115 HARVARD UNIV,SCH MED,DEPT RADIOL BOSTON MA 02115 MASSACHUSETTS GEN HOSP BOSTON MA 02114 BRIGHAM & WOMENS HOSP,DEPT MED,DIV PSYCHIAT BOSTON MA 02115
Titolo Testata:
Biological psychiatry
fascicolo: 11, volume: 42, anno: 1997,
pagine: 1000 - 1005
SICI:
0006-3223(1997)42:11<1000:CIRCBF>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPRESSION; SPECT;
Keywords:
CEREBRAL BLOOD FLOW; SEASONAL AFFECTIVE DISORDER; LIGHT TREATMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
R.G. Vasile et al., "CHANGES IN REGIONAL CEREBRAL BLOOD-FLOW FOLLOWING LIGHT TREATMENT FORSEASONAL AFFECTIVE-DISORDER - RESPONDERS VERSUS NONRESPONDERS", Biological psychiatry, 42(11), 1997, pp. 1000-1005

Abstract

Background: Several brain imaging studies of antidepressant pharmacologic treatment utilizing single photon emission computed tomography (SPECT) have reported a normalization of deficits in cerebral bloodflow (CBF) associated with recovery; other studies report no change, or a reduction in CBF following successful treatment. There have been no published SPECT studies of seasonal affective disorder (SAD) assessing response to light treatment in relation to changes in regional CBF (rCBF), In this study, we sought to test the hypothesis that increases in rCBF would be observed in SAD patients who responded to light treatment. Methods: Ten depressed patients with SAD underwent functional brain imaging studies with Tc-99m-hexamethylpropyleneamine oxime SPECT before and after light treatment. Results: Relative increases in rCBF were observed in all brain regions compared to cerebellum in treatment responders, whereas nonresponders showed no change or decreases in rCBF relative to cerebellum. Significant differences in mean percentage change in rCBF between responders (n = 5) and nonresponders (n = 5) were detected in frontal and cingulate cortex, and thalamus. Conclusions: These findings provide preliminary support for the hypothesis that an increase in rCBF is associated with recovery from depression in SAD. (C) 1997 Society of Biological Psychiatry.

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Documento generato il 06/07/20 alle ore 09:00:45