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Titolo:
DIFFERENTIAL REGULATION OF D-2 AND D-4 DOPAMINE-RECEPTOR MESSENGER-RNAS IN THE PRIMATE CEREBRAL-CORTEX VS. NEOSTRIATUM - EFFECTS OF CHRONICTREATMENT WITH TYPICAL AND ATYPICAL ANTIPSYCHOTIC-DRUGS
Autore:
LIDOW MS; GOLDMANRAKIC PS;
Indirizzi:
UNIV MARYLAND,DEPT ORAL & CRANIOFACIAL BIOL SCI,5-A-12,HHH,666 W BALTIMORE ST BALTIMORE MD 21201 YALE UNIV,SCH MED,NEUROBIOL SECT NEW HAVEN CT 06510
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 2, volume: 283, anno: 1997,
pagine: 939 - 946
SICI:
0022-3565(1997)283:2<939:DRODAD>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLOZAPINE-TREATED PATIENTS; RAT FRONTAL-CORTEX; D2 DOPAMINE; D4 RECEPTORS; SCHIZOPHRENIA; HALOPERIDOL; BRAIN; STRIATUM; HYPOTHESIS; OCCUPANCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Lidow e P.S. Goldmanrakic, "DIFFERENTIAL REGULATION OF D-2 AND D-4 DOPAMINE-RECEPTOR MESSENGER-RNAS IN THE PRIMATE CEREBRAL-CORTEX VS. NEOSTRIATUM - EFFECTS OF CHRONICTREATMENT WITH TYPICAL AND ATYPICAL ANTIPSYCHOTIC-DRUGS", The Journal of pharmacology and experimental therapeutics, 283(2), 1997, pp. 939-946

Abstract

The RNase Protection Assay was used to examine the regulation of D-2 and D-4 dopamine receptor mRNAs in the cerebral cortex and neostriatumof nonhuman primates after chronic treatment with a wide spectrum of antipsychotic medications (chlorpromazine, clozapine, haloperidol, molindone, olanzapine, pimozide, remoxipride and risperidone). Tiapride, a D-2 antagonist that lacks antipsychotic activity, was also included. All drugs were administered orally for 6 months at doses recommended for humans. All antipsychotic drug treatments examined in this study caused a statistically significant up-regulation of both the long and short isoforms of the D-2 receptor mRNAs in the prefrontal and temporalcortex. Tiapride, in contrast, significantly up-regulated only the level of D-2-long mRNA in these areas. The same drug treatments producedless uniform effects in the neostriatum than in the cortex: clozapineand olanzapine failed to significantly elevate either D-2-long or D-2-short receptor messages in this structure unlike all other drugs, including tiapride. In both the cerebral cortex and striatum, D-4 receptor mRNA was upregulated by certain typical (chlorpromazine and haloperidol) and certain atypical (clozapine, olanzapine and risperidone) antipsychotic agents as well as by tiapride. Other drugs of the typical (molindone and pimozide) and atypical (remoxipride) classes had no effect on D-4 mRNA levels in either cortical or striatal tissue. The finding that up-regulation of D-2 dopamine receptor mRNAs was a consistentlyobserved effect of a wide range of antipsychotic agents in the cerebral cortex but not in the neostriatum, coupled with the fact that the D-2-short isoforms in the cortex were not regulated by a nonantipsychotic D-2 antagonist, tiapride, draws attention to the importance of the D-2 dopamine receptor in the cerebral cortex as a potentially critical, common site of action of antipsychotic medications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:17:17