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Titolo:
CHARACTERIZATION OF THE DISCRIMINATIVE STIMULUS PRODUCED BY THE DOPAMINE ANTAGONIST TIAPRIDE
Autore:
COHEN C; SANGER DJ; PERRAULT G;
Indirizzi:
SYNTHELABO RECH,CNS RES DEPT,31 AVE P VAILLANT COUTURIER F-92220 BAGNEUX FRANCE
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 2, volume: 283, anno: 1997,
pagine: 566 - 573
SICI:
0022-3565(1997)283:2<566:COTDSP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTITUTED BENZAMIDE DRUGS; ANTIPSYCHOTIC-DRUGS; RECEPTOR; CLOZAPINE; PHARMACOLOGY; INVITRO; SYSTEM; RATS; HALOPERIDOL; OLANZAPINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
C. Cohen et al., "CHARACTERIZATION OF THE DISCRIMINATIVE STIMULUS PRODUCED BY THE DOPAMINE ANTAGONIST TIAPRIDE", The Journal of pharmacology and experimental therapeutics, 283(2), 1997, pp. 566-573

Abstract

The ability of tiapride, a selective D-2/D-3 dopamine receptor antagonist, to exert discriminative stimulus control of responding was investigated by training rats to discriminate this drug (30 mg/kg) from saline in a two-lever, food-reinforcement procedure. Acquisition of tiapride discrimination required a relatively lengthy training period (meanof 76 sessions) but stable performance was maintained throughout the 18-month study. The dose of tiapride eliciting 50% tiapride-lever choice (ED50) was 2.2 mg/kg. After determination of the dose-effect curve with tiapride, substitution tests with several dopamine antagonists and other reference compounds were performed. All dopamine antagonists, including amisulpride (ED50 4 mg/kg), sulpiride (18 mg/kg), sultopride(1.5 mg/kg), clebopride (0.13 mg/kg), raclopride (0.16 mg/kg), metoclopramide (1.4 mg/kg), remoxipride (4.8 mg/kg), pimozide (2.7 mg/kg), thioridazine (3.4 mg/kg), olanzapine (0.97 mg/kg), chlorpromazine (1.9 mg/kg), risperidone (0.22 mg/kg) and haloperidol (0.14 mg/kg), except clozapine (>10 mg/kg), produced dose-dependent substitution for tiapride. Tiapride-like stimulus effects were observed at doses that decreased response rates. However, ED50 values for substitution by tiapride, amisulpride, sulpiride, sultopride, pimozide, clebopride and thioridazine were lower than ED50 values for decreasing responding. Additional studies were conducted to evaluate the ability of direct and indirect dopamine agonists to attenuate the tiapride discriminative stimulus. Pretreatment with d-amphetamine and nomifensine antagonized the discriminative stimulus effects of tiapride. Quinpirole, 7-OH-DPAT, bromocriptine and apomorphine partially blocked the stimulus effects of tiapride whereas SKF 38393 did not affect the discrimination. These results from substitution and antagonism tests indicated that the discriminative effects of tiapride are mediated by activity at D-2/D-3 dopamine receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:06:36