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Titolo:
SURVIVAL SUPERIORITY OF FEMALES WITH MELANOMA - A MULTIVARIATE-ANALYSIS OF 6383 PATIENTS EXPLORING THE SIGNIFICANCE OF GENDER IN PROGNOSTICOUTCOME
Autore:
STIDHAM KR; JOHNSON JL; SEIGLER HF;
Indirizzi:
DUKE UNIV,MED CTR,DEPT SURG,POB 3966 DURHAM NC 27710 DUKE UNIV,SCH MED,CTR COMPREHENS CANC DURHAM NC 00000 DUKE UNIV,MED CTR,DEPT MICROBIOL & IMMUNOL,DIV GEN & THORAC SURG DURHAM NC 27710
Titolo Testata:
Archives of surgery
fascicolo: 3, volume: 129, anno: 1994,
pagine: 316 - 324
SICI:
0004-0010(1994)129:3<316:SSOFWM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALIGNANT-MELANOMA; SKIN MELANOMA; SEX; DISEASE; STAGE; SITE; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
K.R. Stidham et al., "SURVIVAL SUPERIORITY OF FEMALES WITH MELANOMA - A MULTIVARIATE-ANALYSIS OF 6383 PATIENTS EXPLORING THE SIGNIFICANCE OF GENDER IN PROGNOSTICOUTCOME", Archives of surgery, 129(3), 1994, pp. 316-324

Abstract

Objective: To evaluate the effects of gender on prognostic outcome ofpatients with melanoma. Design: Retrospective cohort study, including20 years of follow-up. Setting: Duke University Melanoma Clinic, Durham, NC, a referral. center for patients with melanoma. Patients: Patients with melanoma (N=6383), consisting of 45% females and 55% males, obtained from a referred sample. Eligibility requirements were nonocular melanomas and white race. Main Outcome Measures: Time to metastases and survival. Results: Females with melanoma demonstrated a superior prognostic outcome over males, with a 34% survival advantage and a 28% disease-free advantage. When each of the variables of age, site, Clark's level, histologic type, and tumor thickness was explored for possible influences on prognostic outcome, female survival advantage persisted, although modified by independent variables. The greatest influencecame from the variables of site, Clark's level, and Breslow's thickness. Age, specifically in premenopausal vs postmenopausal age groups, was not significant in altering females' prognostic advantage. A multivariate analysis combining the effects of all the variables resulted infemales still maintaining a 22% survival advantage and a 17% disease-free advantage. Conclusions: Females with melanoma have a significant prognostic advantage over their male counterparts that cannot be fullyexplained by influences from the variables of age, site, Clark's level, histology, and Breslow's thickness. This superior prognostic outcome does not appear to be associated with menstrual status. Evidence does suggest that the protective factor for females occurs at the level of metastases.

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Documento generato il 04/12/20 alle ore 19:43:24