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Titolo:
BIOLOGY AND MECHANISMS OF ACTION OF SYNERGISTICALLY STIMULATED MYELOID PROGENITOR-CELL PROLIFERATION AND SUPPRESSION BY CHEMOKINES
Autore:
BROXMEYER HE; MANTEL CR; ARONICA SM;
Indirizzi:
INDIANA UNIV,SCH MED,WALTHER ONCOL CTR,DEPT MICROBIOL & IMMUNOL,1044 W WALNUT ST,ROOM 302 INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT MED HEMATOL ONCOL INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT MICROBIOL IMMUNOL INDIANAPOLIS IN 46202
Titolo Testata:
Stem cells
, volume: 15, anno: 1997, supplemento:, 1
pagine: 69 - 77
SICI:
1066-5099(1997)15:<69:BAMOAO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MACROPHAGE INFLAMMATORY PROTEIN-1-ALPHA; MONOCYTE CHEMOATTRACTANT PROTEIN-1; INTERFERON-INDUCIBLE PROTEIN-10; PHOSPHOTYROSINE PHOSPHATASE SYP; IL-8 RECEPTOR HOMOLOG; C-KIT LIGAND; GROWTH-FACTOR; MOLECULAR-CLONING; STEEL FACTOR; FUNCTIONAL EXPRESSION;
Keywords:
CELL PROLIFERATION; SYNERGISM; SUPPRESSION; KNOCKOUT MICE; SIGNAL TRANSDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
68
Recensione:
Indirizzi per estratti:
Citazione:
H.E. Broxmeyer et al., "BIOLOGY AND MECHANISMS OF ACTION OF SYNERGISTICALLY STIMULATED MYELOID PROGENITOR-CELL PROLIFERATION AND SUPPRESSION BY CHEMOKINES", Stem cells, 15, 1997, pp. 69-77

Abstract

A number of cytokines can act together to stimulate/enhance the proliferation of hematopoietic stem and progenitor cells in a greater than additive fashion. An example of this is the combination of a colony-stimulating factor with a potent costimulating molecule such as steel factor. Certain members of the chemokine family of cytokines can suppress this synergistically enhanced proliferation. This review focuses on cytokines involved in these stimulating/enhancing/suppressing effects with regard to biological activity and what is beginning to be learnedabout the intracellular signal transduction events that mag be mediating these effects. Examples of intracellular mediators involved include, but are not limited to, the Raf-1/MAP kinase pathway and cyclin-dependent kinase inhibitors p21(cip-1) and p27(kip-1) for cell proliferation, and eukaryotic initiation factor-4E and 4E binding protein 1 for protein synthesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 01:42:35