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Titolo:
CEREBROSPINAL-FLUID HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 RNA LEVELS ARE ELEVATED IN NEUROCOGNITIVELY IMPAIRED INDIVIDUALS WITH ACQUIRED-IMMUNODEFICIENCY-SYNDROME
Autore:
ELLIS RJ; HSIA K; SPECTOR SA; NELSON JA; HEATON RK; WALLACE MR; ABRAMSON I; ATKINSON JH; GRANT I; MCCUTCHAN JA; MARCOTTE T; CHANDLER JL; JERNIGAN T; MASLIAH E; ABRAMSON I; DUPONT R;
Indirizzi:
UNIV CALIF SAN DIEGO,HIV NEUROBEHAV RES CTR,DEPT NEUROSCI,2760 5TH AVE SAN DIEGO CA 92103 UNIV CALIF SAN DIEGO,DEPT PEDIAT SAN DIEGO CA 92103 UNIV CALIF SAN DIEGO,DEPT PSYCHIAT SAN DIEGO CA 92103 UNIV CALIF SAN DIEGO,DEPT MED SAN DIEGO CA 92103 UNIV CALIF SAN DIEGO,DEPT MATH SAN DIEGO CA 92103 USN HOSP,DEPT MED SAN DIEGO CA 92134 SAN DIEGO VA MED CTR SAN DIEGO CA 00000
Titolo Testata:
Annals of neurology
fascicolo: 5, volume: 42, anno: 1997,
pagine: 679 - 688
SICI:
0364-5134(1997)42:5<679:CHTRLA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; CENTRAL-NERVOUS-SYSTEM; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; HIV-1 PROVIRAL DNA; NEUROLOGIC ABNORMALITIES; SEROPOSITIVE INDIVIDUALS; VIROLOGICAL MARKERS; QUANTITATION; INFECTION; AIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Ellis et al., "CEREBROSPINAL-FLUID HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 RNA LEVELS ARE ELEVATED IN NEUROCOGNITIVELY IMPAIRED INDIVIDUALS WITH ACQUIRED-IMMUNODEFICIENCY-SYNDROME", Annals of neurology, 42(5), 1997, pp. 679-688

Abstract

To determine whether cerebrospinal fluid (CSF) viral burden measurements can assist in the evaluation of human immunodeficiency virus (HIV)-associated neurocognitive disorders, we quantified HIV type 1 (HIV-I)RNA in CSF. Because previous findings suggested that disease stage, lymphocytic pleocytosis, and HIV-1 RNA levels in plasma may influence CSF viral burden, these variables were examined as potential modifying factors. HIV-1 RNA levels were quantified by using a reverse transcriptase-polymerase chain reaction assay. Performance on a comprehensive neuropsychological (NP) battery was noted in 97 prospectively enrolled,HIV-infected subjects. Among subjects with acquired immunodeficiency syndrome (AIDS) (<200 CD4(+) lymphocytes), NP impairment was associated with significantly higher CSF RNA levels (3.1 vs 1.8 log(10) copies/ml; p = 0.02); most impaired subjects met criteria for HIV-associated dementia or minor cognitive-motor disorder. In subjects without AIDS, CSF RNA and NP impairment were unrelated. Before AIDS, CSF RNA was strongly correlated to plasma RNA and to pleocytosis, but in AIDS, CSF and plasma RNA were independent In conclusion, we found elevated CSF HIV-1 RNA levels in NP impaired subjects with AIDS. Before AIDS, systemicviral replication, possibly through CD4(+) mononuclear cell trafficking, map govern virus levels in CSF, whereas in AIDS, CD4 cell depletion may unmask a correlation between increased productive central nervous system HIV infection and clinical neurocognitive disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 21:40:02