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Titolo:
EVALUATION OF RISK-FACTORS FOR ALZHEIMERS-DISEASE IN ELDERLY EAST AFRICANS
Autore:
KALARIA RN; OGENGO JA; PATEL NB; SAYI JG; KITINYA JN; CHANDE HM; MATUJA WB; MTUI EP; KIMANI JK; PREMKUMAR DRD; KOSS E; GATERE S; FRIEDLAND RP;
Indirizzi:
CASE WESTERN RESERVE UNIV,DEPT NEUROL BRB5,10900 EUCLID AVE CLEVELANDOH 44106 CASE WESTERN RESERVE UNIV,UH ALZHEIMER CTR CLEVELAND OH 44106 UNIV NAIROBI,DEPT HUMAN ANAT NAIROBI KENYA UNIV NAIROBI,DEPT MED PHYSIOL NAIROBI KENYA AVE HOSP NAIROBI KENYA MUHIMBILI MED CTR,NEUROL UNIT DAR ES SALAAM TANZANIA MUHIMBILI MED CTR,DEPT PATHOL DAR ES SALAAM TANZANIA
Titolo Testata:
Brain research bulletin
fascicolo: 5, volume: 44, anno: 1997,
pagine: 573 - 577
SICI:
0361-9230(1997)44:5<573:EORFAI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-E EPSILON-4; CORONARY HEART-DISEASE; NIGERIAN-AFRICANS; ALLELE; DEMENTIA; EPIDEMIOLOGY; PREVALENCE; POPULATION; FREQUENCY; POLYMORPHISM;
Keywords:
ALZHEIMERS DISEASE; APOLIPOPROTEIN E; CEREBRAL AMYLOID; DEMENTIA; EAST AFRICA; EPIDEMIOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
R.N. Kalaria et al., "EVALUATION OF RISK-FACTORS FOR ALZHEIMERS-DISEASE IN ELDERLY EAST AFRICANS", Brain research bulletin, 44(5), 1997, pp. 573-577

Abstract

A number of biological risk factors have been implicated for Alzheimer's disease (AD). The investigation of prevalence rates of AD in crosscultural populations has much potential in validating these factors. We previously assessed brain amyloid beta (A beta) protein deposition and other lesions associated with AD as possible markers for preclinical AD in elderly nondemented East Africans. In further analysis, we demonstrate that 17-19% of elderly East African subjects without clinicalneurological disease exhibited neocortical A beta deposits and minimal neurofibrillary changes at necropsy that was qualitatively and quantitatively similar to that in an age-matched elderly control sample from Cleveland, OH, A beta deposits varied from numerous diffuse to highly localized neuritic plaques and were predominantly reactive for the longer A beta(42) species. In parallel studies, we evaluated another recently implicated factor in AD, the apolipoprotein E genotype. We found relatively high frequencies of the apolipoprotein E-epsilon 4 allelein elderly nondemented East Africans. The frequencies were comparableto those in other African populations but higher than in subjects from developed countries. Our limited study suggests that elderly East Africans acquire cerebral lesions found in AD subjects but the apolipoprotein E-epsilon 4 allele may not be a highly specific factor for the disease among East Africans. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 22:40:19