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Titolo:
GENETIC-POLYMORPHISM OF DRUG-METABOLIZING-ENZYMES IN AFRICAN POPULATIONS - IMPLICATIONS FOR THE USE OF NEUROLEPTICS AND ANTIDEPRESSANTS
Autore:
MASIMIREMBWA CM; HASLER JA;
Indirizzi:
UNIV UPPSALA,CTR BIOMED,DEPT PHARMACEUT BIOSCI,DIV MICROBIOL,POB 581 S-75123 UPPSALA SWEDEN UNIV ZIMBABWE,DEPT BIOCHEM HARARE ZIMBABWE
Titolo Testata:
Brain research bulletin
fascicolo: 5, volume: 44, anno: 1997,
pagine: 561 - 571
SICI:
0361-9230(1997)44:5<561:GODIAP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEBRISOQUIN HYDROXYLATION PHENOTYPE; HUMAN LIVER-MICROSOMES; S-MEPHENYTOIN; POOR METABOLIZERS; CYTOCHROME-P450 CYP2D6; ZIMBABWEAN POPULATION; EUROPEAN POPULATION; SPARTEINE OXIDATION; LOWER PREVALENCE; PLASMA-LEVELS;
Keywords:
CYTOCHROME P450; PSYCHOACTIVE DRUGS; INTERINDIVIDUAL AND INTERETHNIC VARIATION; POLYMORPHISMS IN AFRICA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
81
Recensione:
Indirizzi per estratti:
Citazione:
C.M. Masimirembwa e J.A. Hasler, "GENETIC-POLYMORPHISM OF DRUG-METABOLIZING-ENZYMES IN AFRICAN POPULATIONS - IMPLICATIONS FOR THE USE OF NEUROLEPTICS AND ANTIDEPRESSANTS", Brain research bulletin, 44(5), 1997, pp. 561-571

Abstract

Metabolism of most drugs influences their pharmacological and toxicological effects, Drugs particularly affected are those with a narrow therapeutic window and that are subjected to considerable first-pass metabolism. Much of the interindividual and interethnic differences in effects of drugs is now attributable to genetic differences in their metabolism. Genetic polymorphisms have been described for many drug-metabolising enzymes in Caucasian and Oriental populations, the most well-characterised being those for cytochrome P450 2D6, cytochrome P450 2C19, glutathione S-transferases, and N-acetyl transferase 2. African populations have been studied to a lesser extent, but it is apparent that populations within Africa are heterogeneous with respect to these polymorphisms, In addition, although some allelic variants are common to all populations throughout the world (e.g., CYP2D65), some allelic variants are specific for an African population (e.g., CYP2D617), The polymorphisms give rise to enzymes with changed or no activity towards drug substrates. Two of the most important enzymes for metabolism of neuroleptics and other psychoactive drugs are CYP2D6 and CYP2C19. This article compares the current information on polymorphisms of these two enzymes in African and other populations and discusses the implications of these polymorphisms for neuropharmacotherapy. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:34:59