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Titolo:
DYNAMIC P-31 MAGNETIC-RESONANCE SPECTROSCOPY IN ARTERIAL OCCLUSIVE DISEASE - CORRELATION WITH CLINICAL AND ANGIOGRAPHIC FINDINGS AND COMPARISON WITH HEALTHY-VOLUNTEERS
Autore:
SCHUNK K; ROMANEEHSEN B; MILDENBERGER P; KERSJES W; SCHADMANDFISCHER S; THELEN M;
Indirizzi:
UNIV HOSP MAINZ,DEPT RADIOL,LANGENBECKSTR 1 D-55131 MAINZ GERMANY
Titolo Testata:
Investigative radiology
fascicolo: 11, volume: 32, anno: 1997,
pagine: 651 - 659
SICI:
0020-9996(1997)32:11<651:DPMSIA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SKELETAL-MUSCLE; CHRONIC HEART-FAILURE; NMR-SPECTROSCOPY; CALF MUSCLE; P-31; METABOLISM; EXERCISE; INSUFFICIENCY; RECOVERY;
Keywords:
P-31; MAGNETIC RESONANCE SPECTROSCOPY; MUSCULAR METABOLISM; QUADRICEPS MUSCLE; ARTERIAL OCCLUSIVE DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
K. Schunk et al., "DYNAMIC P-31 MAGNETIC-RESONANCE SPECTROSCOPY IN ARTERIAL OCCLUSIVE DISEASE - CORRELATION WITH CLINICAL AND ANGIOGRAPHIC FINDINGS AND COMPARISON WITH HEALTHY-VOLUNTEERS", Investigative radiology, 32(11), 1997, pp. 651-659

Abstract

RATIONALE AND OBJECTIVES. The aim of this prospective study was to explore muscular metabolism in arterial occlusive disease (AOD) by dynamic phosphorus-31 (P-31) magnetic resonance spectroscopy (MRS). METHODS. The authors examined 56 patients with AOD. Acquisition of up to 60 consecutive phosphorus spectra of the quadriceps muscle was done by ''time series'' in 36 seconds each. In this way, the authors achieved uninterrupted monitoring of muscle metabolism during rest, exhaustion, and recovery. During P-31 MRS, the volunteers performed an isometric andan isotonic exercise until exhaustion of the quadriceps muscle. Spectroscopic results of 56 patients with AOD were correlated with clinicaland angiographic findings and were compared with spectroscopic results of 10 age-matched healthy volunteers. RESULTS. There were no significantly differing spectroscopic results between patients and volunteersat rest, except for an elevated ratio phosphomonoester (PME)/beta-adenosine triphosphate (ATP) in patients with AOD (0.66 +/- 0.19 versus 0.48 +/- 0.09). Despite a sixfold duration of both of the exercises until exhaustion in healthy volunteers, exercise-induced changes of inorganic phosphate (P-i)/phosphocreatine (PCr), PME/beta-ATP, and pH were similar in healthy volunteers and patients with AOD. Compared with maximal exercise-induced values of P-i/PCr, acidosis was relatively increased in AOD, resulting in a steeper slope of linear regression line (-0.33 +/- 0.06 versus -0.14 +/- 0.06) between these parameters. Recovery rate of P-i/PCr was markedly prolonged in AOD (time of half recovery: 80 seconds versus 25 seconds [isometric exercise] and 70 seconds versus 37 seconds [isotonic exercise]), whereas recovery rate of pH was not significantly slowed down in our patients (192 seconds versus 166 seconds [isometric exercise] and 234 seconds versus 220 seconds [isotonic exercise]). CONCLUSIONS. Dynamic P-31 MRS provides a direct judgment of muscular metabolism, which is not only influenced by macro-, but also by microangiopathia. Results of P-31 MRS suggest a reduced mitochondrial oxidative phosphorylation in AOD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:56:19