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Titolo:
PLASMA LEPTIN AND ACUTE SEROTONINERGIC STIMULATION OF THE CORTICOTROPIC AXIS IN WOMEN WHO ARE NORMAL-WEIGHT OR OBESE
Autore:
OPPERT JM; LAHLOU N; LAFERRERE B; ROGER M; BASDEVANT A; GUYGRAND B;
Indirizzi:
HOP HOTEL DIEU,SERV MED & NUTR F-75181 PARIS 04 FRANCE HOP ST VINCENT DE PAUL,INSERM,U342,LAB BIOL HORMONALE F-75014 PARIS FRANCE ST LUKES ROOSEVELT HOSP,OBES RES CTR NEW YORK NY 10025 AMER HOSP PARIS F-92202 NEUILLY SUR SEINE FRANCE
Titolo Testata:
Obesity research
fascicolo: 5, volume: 5, anno: 1997,
pagine: 410 - 416
SICI:
1071-7323(1997)5:5<410:PLAASS>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUS FEEDING-BEHAVIOR; OB MESSENGER-RNA; MEAL PATTERNS; GENE-PRODUCT; FOOD-INTAKE; HUMANS; EXPRESSION; PROTEIN; INSULIN; ADIPOSITY;
Keywords:
OB GENE; HUMAN OBESITY; CORTISOL; ACTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Oppert et al., "PLASMA LEPTIN AND ACUTE SEROTONINERGIC STIMULATION OF THE CORTICOTROPIC AXIS IN WOMEN WHO ARE NORMAL-WEIGHT OR OBESE", Obesity research, 5(5), 1997, pp. 410-416

Abstract

In some recent studies, glucocorticoid treatment was associated with rapid induction of obese (ob) gene expression in adipose tissue of normal rats and in isolated adipocytes, We studied the effect of acute stimulation of the corticotropic axis on plasma leptin, the ob gene product, in 7 women of normal weight and 12 women with obesity. Under double-blind, placebo-controlled conditions, a single 12.5-mg dose of clomipramine, a serotonin uptake inhibitor, was administered intravenouslyin 15 minutes, Mean basal plasma leptin was increased more than 3-fold in subjects with obesity compared with subjects of normal weight (35.1 +/- 4.9 ng/mL vs, 8.9 +/- 1.4 ng/mL, p=0.001). Whereas corticotropin (ACTH) and cortisol responses were increased in women who were obesecompared with women who were lean, no significant effect of clomipramine infusion was found on plasma leptin concentrations measured duringthe following 150 minutes in both groups, There was a strong positivecorrelation between basal plasma leptin concentrations and body mass index (r=0.92, p<0.0001). In six subjects with obesity studied after amoderate weight loss, mean basal plasma leptin was significantly decreased (43.7 +/- 6.4 ng/mL before vs. 28.0 +/- 8.1 ng/mL after, p=0.04), but the hormonal response pattern to clomipramine administration wasunchanged, We conclude that, at least in the short term, an acute stimulation of the corticotropic asis does not seem to increase leptin secretion in humans, as shown by the response to the serotoninergic agent clomipramine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:13:06