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Titolo:
COORDINATE REGULATION OF THE EXPRESSION OF THE FATTY-ACID TRANSPORT PROTEIN AND ACYL-COA SYNTHETASE GENES BY PPAR-ALPHA AND PPAR-GAMMA ACTIVATORS
Autore:
MARTIN G; SCHOONJANS K; LEFEBVRE AM; STAELS B; AUWERX J;
Indirizzi:
INST PASTEUR,U325 INSERM,DEPT ATHEROSCLEROSE,1 RUE CALMETTE F-59019 LILLE FRANCE INST PASTEUR,U325 INSERM,DEPT ATHEROSCLEROSE F-59019 LILLE FRANCE
Titolo Testata:
The Journal of biological chemistry
fascicolo: 45, volume: 272, anno: 1997,
pagine: 28210 - 28217
SICI:
0021-9258(1997)272:45<28210:CROTEO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENHANCES ADIPOCYTE DIFFERENTIATION; HORMONE RECEPTOR SUPERFAMILY; INSULIN-SENSITIZING AGENT; PEROXISOME PROLIFERATOR; LIPID-METABOLISM; CDNA CLONING; PIOGLITAZONE; GLUCOSE; CELLS; BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
G. Martin et al., "COORDINATE REGULATION OF THE EXPRESSION OF THE FATTY-ACID TRANSPORT PROTEIN AND ACYL-COA SYNTHETASE GENES BY PPAR-ALPHA AND PPAR-GAMMA ACTIVATORS", The Journal of biological chemistry, 272(45), 1997, pp. 28210-28217

Abstract

Intracellular fatty acid (FA) concentrations are in part determined by a regulated import/export system that is cent-rolled by two key proteins, i.e. fatty acid transport protein (FATP) and acyl-CoA synthetase(ACS), which respectively facilitate the transport of FAs across the cell membrane and their esterification to prevent their efflux, The aim of this investigation was to analyze the expression pattern of FATP and ACS and to determine whether their expression was altered by agents that affect FA metabolism through the activation of peroxisome proliferator-activated receptors (PPAR) such as the fibrates and thiazolidinediones, FATP mRNA was ubiquitously expressed, with highest levels being detected in adipose tissue, heart, brain, and testis. Fibrate treatment, which is known to preferentially activate PPAR gamma, induced FATP mRNA levels in rat liver and intestine and induced ACS mRNA levelsin liver and kidney, The antidiabetic thiazolidinedione BRL 49653, which is a high-affinity ligand for the adipocyte-specific PPAR gamma form, caused a small induction of muscle but a robust induction of adipose tissue FATP mRNA levels. BRL 49653 did not affect liver FATP and had a tendency to decrease heart FATP mRNA levels, ACS mRNA levels in general showed a similar pattern after BRL 49653 as FATP except for the muscle where ACS mRNA was induced, This regulation of FATP and ACS expression by PPAR activators was shown to be at the transcriptional level and could also be reproduced in vitro in cell culture systems, In the hepatocyte cell lines AML-12 or Fa 32, fenofibric acid, but not BRL 49653, induced FATP and ACS mRNA levels, whereas in the 3T3-L1 preadipocyte cell line, the PPAR gamma ligand induced FATP and ACS mRNA levels quicker than fenofibric acid, Inducibility of ACS and FATP mRNA by PPAR alpha or gamma activators correlated with the tissue-specific distribution of the respective PPARs and was furthermore associated with aconcomitant increase in FA uptake, Most interestingly, thiazolidinedione antidiabetic agents seem to favor adipocyte-specific FA uptake relative to muscle, perhaps underlying in part the beneficial effects of these agents on insulin-mediated glucose disposal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 15:00:58