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Titolo:
ACTIVATION MARKERS OF THE CLOTTING AND FI BRINOLYTIC SYSTEMS IN NEWBORN
Autore:
RIES M; KLINGE J; RAUCH R; ZENKER M; AYDIN I; HARMS D;
Indirizzi:
UNIV ERLANGEN NURNBERG,KLIN POLIKLIN KINDER & JUGENDLICHE,NEONATOL ABT,LOSCHGESTR 15 D-91054 ERLANGEN GERMANY
Titolo Testata:
Klinische Padiatrie
fascicolo: 6, volume: 208, anno: 1996,
pagine: 350 - 354
SICI:
0300-8630(1996)208:6<350:AMOTCA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
GER
Soggetto:
DISSEMINATED INTRAVASCULAR COAGULATION; RESPIRATORY-DISTRESS SYNDROME; PROTHROMBIN FRAGMENT 1+2; FULL-TERM NEWBORN; DYSFUNCTIONAL PLASMINOGEN; NEONATAL HEMOSTASIS; THROMBIN; PLASMA; FIBRINOGEN; INFANTS;
Keywords:
FIBRINOLYSIS; COAGULATION; ACTIVATION MARKERS; NEWBORNS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
M. Ries et al., "ACTIVATION MARKERS OF THE CLOTTING AND FI BRINOLYTIC SYSTEMS IN NEWBORN", Klinische Padiatrie, 208(6), 1996, pp. 350-354

Abstract

Background Activation markers of the clotting and fibrinolytic systems are elevated immediately after birth and decline to near adult levels during the first 24 hours of life. The aims of this study were to investigate, whether the activation of both clotting and fibrinolysis isdependent on the mode of delivery, and to measure activation markers in newborns with infection beyond the first days of life. Patients We have studied activation markers thrombin-antithrombin III complex, prothrombin fragment 1+2, D-dimer and plasmin-antiplasmin complex by use of commercially available ELISA techniques in 20 newborns after elective Cesarean sections because of previous sections. in 20 newborns after Cesarean sections and a trial of labor with uterine contractions over a period of >20 hours and in 20 newborns (34.-41. gestational week) aged 10-25 days with infection. 20 healthy adults served as controls. Results A significant elevation of all activation markers was observedboth in the newborns after Cesarean sections and in the 10-25 days old children with infection. There were no differences among newborns after elective sections compared to newborns after section and a trial of labor with uterine contractions over a period of >20 hours. Conclusions The clotting and fibrinolytic systems reveal increased activation immediately after delivery, but uterine contractions over a period of >20 hours seem not to make a difference. During infection, the activation markers of the hemostatic system in newborns aged 10-25 days behaves similarly to the mature adult system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:14:37