Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INFLAMMATORY MEDIATORS IN BAL FLUID AS MARKERS OF EVOLVING PNEUMONIA IN LEUKOCYTOPENIC PATIENTS
Autore:
KIEHL MG; OSTERMANN H; THOMAS M; BIRKFELLNER T; KIENAST J;
Indirizzi:
UNIV MUNSTER,DEPT INTERNAL MED,HEMATOL ONCOL SECT,ALBERT SCHWEITZER STR 33 D-48129 MUNSTER GERMANY
Titolo Testata:
Chest
fascicolo: 5, volume: 112, anno: 1997,
pagine: 1214 - 1220
SICI:
0012-3692(1997)112:5<1214:IMIBFA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS-SYNDROME; TUMOR-NECROSIS-FACTOR; BRONCHOALVEOLAR LAVAGE; SEPTIC SHOCK; NEUTROPENIA; CYTOKINES; RISK; INTERLEUKIN-8; NEUTROPHILS; COMPLEMENT;
Keywords:
BRONCHOALVEOLAR LAVAGE; CYTOKINES; INFLAMMATORY MEDIATORS; LEUKOCYTOPENIA; PNEUMONIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
M.G. Kiehl et al., "INFLAMMATORY MEDIATORS IN BAL FLUID AS MARKERS OF EVOLVING PNEUMONIA IN LEUKOCYTOPENIC PATIENTS", Chest, 112(5), 1997, pp. 1214-1220

Abstract

Study objectives: Pneumonia during chemotherapy-induced leukocytopenia is a major cause of overall treatment failure in patients with hematologic malignancies. To improve outcome in these high-risk patients, early diagnosis of pulmonary infiltrates and institution of adequate antimicrobial treatment are mandatory. To identify patients with evolving pneumonia, we have prospectively studied the prognostic value of cytokine and complement measurements in early BAL samples from febrile leukocytopenic patients. Design: Prospective, comparative study. Setting: Hematology/oncology section of a university hospital. Patients: Twenty-one patients with leukocytopenia (WBC count <1.000/mu L) following cytoreductive chemotherapy for malignant disorders, Intervention: Early BAL sampling primarily for microbiologic diagnostic purposes. Measurements and results: Proinflammatory cytokines and activated complementcomponents were measured in the BAL aspirates and the results were related to the prevalence or subsequent evolution of overt pneumonia. Ofthe 21 patients studied, 10 patients presented with overt pneumonia at BAL sampling (group A), 5 patients developed objective signs of pneumonia 3 to 5 days after BAL (group B), and 6 patients remained free ofpneumonia during follow-up (group C), In comparison with group C, patients in groups A and B both had distinctly elevated bronchoalveolar levels of tumor necrosis factor-alpha, interleukin-6, granulocyte colony-stimulating factor, C3a, and C5a, Conclusions: Cytokine and complement determinations in early BAL samples may aid in the identification of febrile leukocytopenic patients with evolving pneumonia 3 to 5 days prior to the manifestation of diagnostic clinical and radiographic signs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 09:50:16