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Titolo:
EFFECT OF HIGH-FREQUENCY ELECTRICAL-STIMULATION OF THE AUDITORY-NERVEIN AN ANIMAL-MODEL OF COCHLEAR IMPLANTS
Autore:
VISCHER M; HAENGGELI A; ZHANG JS; PELIZZONE M; HAUSLER R; ROUILLER EM;
Indirizzi:
UNIV BERN,INSELSPITAL,CLIN ENT HEAD & NECK SURG CH-3010 BERN SWITZERLAND UNIV GENEVA,HOP CANTONAL,DEPT ENT HEAD & NECK SURG CH-1211 GENEVA SWITZERLAND UNIV FRIBOURG,INST PHYSIOL CH-1700 FRIBOURG SWITZERLAND
Titolo Testata:
The American journal of otology
fascicolo: 6, volume: 18, anno: 1997, supplemento:, S
pagine: 27 - 29
SICI:
0192-9763(1997)18:6<27:EOHEOT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPEECH RECOGNITION;
Keywords:
AUDITORY NERVE; COCHLEAR TRANSPLANT; AUDITORY BRAIN-STEM RESPONSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
7
Recensione:
Indirizzi per estratti:
Citazione:
M. Vischer et al., "EFFECT OF HIGH-FREQUENCY ELECTRICAL-STIMULATION OF THE AUDITORY-NERVEIN AN ANIMAL-MODEL OF COCHLEAR IMPLANTS", The American journal of otology, 18(6), 1997, pp. 27-29

Abstract

Hypothesis: Electrical stimulation of the cochlea at high rates induces significant adaptation of the auditory nerve. Background: A new development of cochlear implants is the use of speech processors delivering electrical pulses on the implanted electrodes at high rates, such as 1,000 pulses per second (pps) and above. Such a stimulation mode allows subjects with cochlear implants to reach excellent understanding of speech. Methods: Long Evans-rats received implantation of stimulating electrodes in the left cochlea. Two hundred-millisecond trains of short (20 mu s) monophasic pulses were delivered in 50% duty cycle at 500 mu A above threshold. The pulse rate in the train was increased from100 pps to 1,500 pps. Electrically evoked auditory brainstem responses (EABR) were recorded. The amplitude of the compound action potentialof the auditory nerve to each single pulse in the train was measured as the first vertex positive wave (WAVE I) of the EABR. Results: At 100 and 200 pps, WAVE I amplitudes to each pulse were large and remainedstable throughout the pulse train. For increasing pulse rates, WAVE Iamplitudes progressively decreased during the first 40 to 50 ms of the train and reached 80% at 300 pps to 15% at 1,500 pps of the maximal amplitude observed for the first pulse in the train. Conclusions: The decrease of the WAVE I amplitude in response to high-rate pulsatile stimulation reflects an adaptation of the auditory nerve due, at least in part, to the refractory period of auditory nerve fibers.

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Documento generato il 04/12/20 alle ore 15:57:13