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Titolo:
DOPAMINERGIC NEUROTOXIN ADMINISTRATION TO THE AREA OF THE SUPRACHIASMATIC NUCLEI INDUCES INSULIN-RESISTANCE
Autore:
LUO SQ; LUO J; MEIER AH; CINCOTTA AH;
Indirizzi:
ERGO SCI CORP,100 1ST AVE CHARLESTOWN MA 02129
Titolo Testata:
NeuroReport
fascicolo: 16, volume: 8, anno: 1997,
pagine: 3495 - 3499
SICI:
0959-4965(1997)8:16<3495:DNATTA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESOCRICETUS-AURATUS; GULF KILLIFISH; NEURONS; RESPONSES; HAMSTER; BRAIN;
Keywords:
DOPAMINERGIC NEUROTOXIN; CIRCADIAN REGULATION; GLUCOSE INTOLERANCE; HYPOTHALAMIC SUPRACHIASMATIC NUCLEI; INSULIN RESISTANCE; SYRIAN HAMSTER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
S.Q. Luo et al., "DOPAMINERGIC NEUROTOXIN ADMINISTRATION TO THE AREA OF THE SUPRACHIASMATIC NUCLEI INDUCES INSULIN-RESISTANCE", NeuroReport, 8(16), 1997, pp. 3495-3499

Abstract

DOPAMINERGIC neuron neurotoxin (6-hydroxydopamine; 6-OHDA) administration directed to the hypothalamic area of the mammalian pacemaker, thesuprachiasmatic nuclei (SCN), was carried out on lean, glucose tolerant hamsters to investigate the possibility that dopaminergic input to the vicinity of the SCN is necessary to maintain this metabolic condition. Glucose tolerance tests (GTT, 3 g glucose/kg) were performed 4 days prior to and 16 days after neurotoxin lesioning. 6-OHDA administration to the area of the SCN resulted in both a significant 58% increasein daily food consumption by the 16th day post-lesioning, and a 85% increase in weight gain 4 and 8 weeks after lesioning relative to controls. Such treatment also significantly increased the total areas underthe GTT glucose and insulin curves by 48% and 400% respectively, compared with controls. These findings indicate that body weight gain, glucose intolerance and insulin resistance result from decreased dopaminergic input to the area of the SCN.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:52:56