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Titolo:
GUANABENZ-RELATED AMIDINOHYDRAZONES - POTENT NONAZOLE INHIBITORS OF ALDOSTERONE BIOSYNTHESIS
Autore:
SOLL RM; DOLLINGS PJ; MITCHELL RD; HAFNER DA;
Indirizzi:
WYETH AYERST RES,DEPT MED CHEM,CN-8000 PRINCETON NJ 08543 WYETH AYERST RES,DIV CARDIOVASC & METAB DIS PRINCETON NJ 08543
Titolo Testata:
European journal of medicinal chemistry
fascicolo: 3, volume: 29, anno: 1994,
pagine: 223 - 232
SICI:
0223-5234(1994)29:3<223:GA-PNI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
DERIVATIVES;
Keywords:
ALDOSTERONE; BIOSYNTHESIS; INHIBITION; GUANABENZ;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
R.M. Soll et al., "GUANABENZ-RELATED AMIDINOHYDRAZONES - POTENT NONAZOLE INHIBITORS OF ALDOSTERONE BIOSYNTHESIS", European journal of medicinal chemistry, 29(3), 1994, pp. 223-232

Abstract

A new series of potent, guanabenz-derived, non-steroidal aldosterone biosynthesis inhibitors are presented. Salient features of the structure-activity relationship indicate the requirement of a hydrophobic core, presence of a hydrophilic (or basic) peripheral appendage, and, in some cases, profound dependence on hydrazone stereochemistry. The mostpotent compound of the series, 29, was 2 orders of magnitude more potent than guanabenz as an aldosterone biosynthesis inhibitor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 09:12:39