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Titolo:
ENDOCRINE RESPONSES DURING ACUTE NICOTINE WITHDRAWAL
Autore:
PICKWORTH WB; BAUMANN MH; FANT RV; ROTHMAN RB; HENNINGFIELD JE;
Indirizzi:
NIDA,ADDICT RES CTR,INTRAMURAL RES PROGRAM,POB 5180 BALTIMORE MD 21224
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 3, volume: 55, anno: 1996,
pagine: 433 - 437
SICI:
0091-3057(1996)55:3<433:ERDANW>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIGARETTE-SMOKING; COCAINE WITHDRAWAL; PROLACTIN; CORTISOL; SMOKERS; SYSTEM;
Keywords:
NICOTINE; TRANSDERMAL NICOTINE; ACTH; CORTISOL; PROLACTIN; NICOTINE ABSTINENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
W.B. Pickworth et al., "ENDOCRINE RESPONSES DURING ACUTE NICOTINE WITHDRAWAL", Pharmacology, biochemistry and behavior, 55(3), 1996, pp. 433-437

Abstract

Acute administration of nicotine increases cortisol and prolactin butthe endocrine effects of tobacco withdrawal are unknown. In a residential, double-blind, placebo-controlled, crossover study, volunteers smoked ad lib for 4 days and underwent monitored tobacco abstinence for 3 days. On no-smoking days, patches delivering 0, 10, 20, or 30 mg nicotine were applied for 16 h. Daily plasma samples were analyzed for ACTH, cortisol, and prolactin. During nicotine abstinence (0 mg patch), circulating levels of ACTH, cortisol, and prolactin did not significantly change from ad lib smoking levels. Over all the patch conditions there was a significant effect of day, with modest but significant elevations of cortisol and ACTH levels on the second no-smoking day (Wed, 37 h abstinent). Prolactin levels increased during nicotine abstinence, but this effect was not significant. The observed endocrine changes did not correlate with physiologic, performance, or subjective measures of tobacco withdrawal. Our data indicate endocrine changes during acute tobacco withdrawal are transient and small. Thus, the present results do not support the use of ACTH as a treatment for tobacco cessation. Copyright (C) 1996 Elsevier Science Inc.

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Documento generato il 10/07/20 alle ore 09:29:14