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Titolo:
VESICULAR NEUROTRANSMITTER TRANSPORTERS - POTENTIAL SITES FOR THE REGULATION OF SYNAPTIC FUNCTION
Autore:
VAROQUI H; ERICKSON JD;
Indirizzi:
LOUISIANA STATE UNIV,MED CTR,CTR NEUROSCI,2020 GRAVIER ST,SUITE D NEWORLEANS LA 70112 LOUISIANA STATE UNIV,MED CTR,CTR NEUROSCI NEW ORLEANS LA 70112 LOUISIANA STATE UNIV,MED CTR,DEPT PHARMACOL NEW ORLEANS LA 70112
Titolo Testata:
Molecular neurobiology
fascicolo: 2, volume: 15, anno: 1997,
pagine: 165 - 191
SICI:
0893-7648(1997)15:2<165:VNT-PS>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSE-CORE VESICLES; MIDBRAIN DOPAMINERGIC-NEURONS; CHROMAFFIN GRANULE MEMBRANE; PHEOCHROMOCYTOMA CELL-LINE; BETA-ADRENERGIC-RECEPTOR; ADRENAL-MEDULLARY CELLS; H-3 VESAMICOL BINDING; MONOAMINE TRANSPORTER; ACETYLCHOLINE TRANSPORTER; CHOLINE-ACETYLTRANSFERASE;
Keywords:
VMAT1; VMAT2; VACHT; VESICULAR MONOAMINE TRANSPORTER; VESICULAR ACETYLCHOLINE TRANSPORTER; CHOLINERGIC GENE LOCUS; GENE KNOCKOUT; LARGE DENSE CORE VESICLES; SMALL SYNAPTIC VESICLES; TARGETING; NEUROTOXICITY; NEURODEGENERATION; PARKINSONS DISEASE; ALZHEIMERS DISEASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
192
Recensione:
Indirizzi per estratti:
Citazione:
H. Varoqui e J.D. Erickson, "VESICULAR NEUROTRANSMITTER TRANSPORTERS - POTENTIAL SITES FOR THE REGULATION OF SYNAPTIC FUNCTION", Molecular neurobiology, 15(2), 1997, pp. 165-191

Abstract

Neurotransmission depends on the regulated release of chemical transmitter molecules. This requires the packaging of these substances into the specialized secretory vesicles of neurons and neuroendocrine cells, a process mediated by specific vesicular transporters. The family ofgenes encoding the vesicular transporters for biogenic amines and acetylcholine have recently been cloned. Direct comparison of their transport characteristics and pharmacology provides information about vesicular transport bioenergetics, substrate feature recognition by each transporter, and the role of vesicular amine storage in the mechanism ofaction of psychopharmacologic and neurotoxic agents. Regulation of vesicular transport activity may affect levels of neurotransmitter available for neurosecretion and be an important site for the regulation ofsynaptic function. Gene knockout studies have determined vesicular transport function is critical for survival and have enabled further evaluation of the role of vesicular neurotransmitter transporters in behavior and neurotoxicity. Molecular analysis is beginning to reveal the sites involved in vesicular transporter function and the sites that determine substrate specificity. In addition, the molecular basis for the selective targeting of these transporters to specific vesicle populations and the biogenesis of monoaminergic and cholinergic synaptic vesicles are areas of research that are currently being explored. This information provides new insights into the pharmacology and physiology of biogenic amine and acetylcholine vesicular storage in cardiovascular, endocrine, and central nervous system function and has important implications for neurodegenerative disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 11:41:17