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Titolo:
DIFFERENTIAL EXPRESSION OF D1 AND D2 DOPAMINE AND M4 MUSCARINIC ACETYLCHOLINE-RECEPTOR PROTEINS IN IDENTIFIED STRIATONIGRAL NEURONS
Autore:
INCE E; CILIAX BJ; LEVEY AI;
Indirizzi:
EMORY UNIV,SCH MED,DEPT NEUROL,WOODRUFF MEM BLDG,SUITE 6000 ATLANTA GA 30322 EMORY UNIV,SCH MED,DEPT NEUROL ATLANTA GA 30322 EMORY UNIV,SCH MED,DIV BIOL & BIOMED SCI,GRAD PROGRAM NEUROSCI ATLANTA GA 30322
Titolo Testata:
Synapse
fascicolo: 4, volume: 27, anno: 1997,
pagine: 357 - 366
SICI:
0887-4476(1997)27:4<357:DEODAD>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBTYPE-SPECIFIC ANTIBODIES; C-FOS EXPRESSION; RAT STRIATUM; BASAL GANGLIA; PHENOTYPICAL CHARACTERIZATION; STRIATOPALLIDAL NEURONS; GENE-EXPRESSION; MESSENGER-RNAS; LOCALIZATION; BRAIN;
Keywords:
D1; D2; DOPAMINE RECEPTORS; M4; ACETYLCHOLINE RECEPTOR; IMMUNOCYTOCHEMISTRY; STRIATUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
E. Ince et al., "DIFFERENTIAL EXPRESSION OF D1 AND D2 DOPAMINE AND M4 MUSCARINIC ACETYLCHOLINE-RECEPTOR PROTEINS IN IDENTIFIED STRIATONIGRAL NEURONS", Synapse, 27(4), 1997, pp. 357-366

Abstract

Large families of genetically distinct G-protein coupled receptor subtypes mediate dopamine's (D1-D5) and acetylcholine's effects (m1-m5). A functional balance of dopamine and acetylcholine may be based in part on the differential expression of receptor subtypes by distinct neuron subpopulations. The localization of the D1 and D2 receptors, the predominant dopamine receptors in neostriatum, to distinct subpopulations of striatal projection neurons has been controversial. In addition, m4 receptor localization to specific striatal projection neuron subpopulations is also at question. To determine whether rat striatonigral neurons differentially express D1, D2, and m4 receptor proteins, we combined immunocytochemistry by using receptor subtype specific antibodies and retrograde tracing with cholera toxin-colloidal gold. D1 and m4 receptor immunoreactivity was visualized in 95% and 92% of identified striatonigral neurons, respectively. By contrast, D2 receptor immunoreactivity was visualized in only 1% of these neurons. These findings support models of basal ganglia in which D1 and D2 receptors are segregated, as well as indicate that D1 and m4 are colocalized. These cellular distributions may be important substrates for the putative DA/ACh balance that is implicated in certain movement disorders. (C) 1997 Wiley-Liss, Inc.

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Documento generato il 04/07/20 alle ore 05:05:40