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Titolo:
EVALUATION OF THE REINFORCING AND DISCRIMINATIVE STIMULUS EFFECTS OF THE N-METHYL-D-ASPARTATE COMPETITIVE ANTAGONIST NPC-17742 IN RHESUS-MONKEYS
Autore:
NICHOLSON KL; JONES HE; BALSTER RL;
Indirizzi:
VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL & TOXICOL,BOX 980310 RICHMOND VA 23298 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL & TOXICOLRICHMOND VA 23298
Titolo Testata:
Behavioural pharmacology
fascicolo: 5, volume: 8, anno: 1997,
pagine: 396 - 407
SICI:
0955-8810(1997)8:5<396:EOTRAD>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA RECEPTOR ANTAGONISTS; FIXED-INTERVAL SCHEDULE; PHENCYCLIDINE-LIKE; SQUIRREL-MONKEYS; D-CPPENE; PHARMACOLOGICAL SPECIFICITY; BEHAVIORAL PHARMACOLOGY; SELF-INJECTION; RATS; COCAINE;
Keywords:
DRUG DISCRIMINATION; MONKEY; NMDA RECEPTOR; NPC 17742; PHENCYCLIDINE; SELF-ADMINISTRATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
K.L. Nicholson et al., "EVALUATION OF THE REINFORCING AND DISCRIMINATIVE STIMULUS EFFECTS OF THE N-METHYL-D-ASPARTATE COMPETITIVE ANTAGONIST NPC-17742 IN RHESUS-MONKEYS", Behavioural pharmacology, 8(5), 1997, pp. 396-407

Abstract

The phencyclidine (PCP)-like effects of the N-methyl-D-aspartate (NMDA) competitive antagonist -2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoic acid (NPC 17742) were evaluated in three behavioral tests in rhesus monkeys. The discriminative stimulus properties of NPC 17742 (2-24 mg/kg, i.m.) were tested in four rhesus monkeys trained to discriminate PCP from saline under a fixed-ratio (FR) 50 schedule of food reinforcement. In three of the monkeys, NPC 17742 showed complete substitution far PCB at doses which did not decrease rates of responding, Intravenous self-administration of NPC 17742 (50-800 mu g/kg/infusion) was tested under a FR schedule of reinforcement in four monkeys trained tolever press for infusions of PCP. At least one dose of NPC 17742 functioned as a reinforcer in two of the monkeys. A second self-administration study, employing a 10 min fixed interval schedule of reinforcement, was performed in three monkeys trained to self-administer PCP during three daily sessions. Compared with PCP, NPC 17742 (0.4-1.6 mg/kg/infusion) maintained very low rates of responding; NPC 17742 could not be clearly established as a reinforcer in this procedure. The data showthat NPC 17742 has some PCP-like behavioral effects, and mag functionas a weak reinforcer in some subjects under specific conditions. The results provide further evidence that both similarities and differences exist between the behavioral effects of PCP and competitive NMDA antagonists.

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Documento generato il 05/12/20 alle ore 01:53:30