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Titolo:
DETECTION RATE AND INTRATUMORAL VIRUS LOAD OF HUMAN-HERPESVIRUS-8 IN IMMUNODEFICIENCY-RELATED B-CELL LYMPHOID MALIGNANCIES
Autore:
FEUILLARD J; AUBIN JT; POIREL L; DAVI F; KUJAS M; ROUSSELET MC; ANGONIN R; RAPHAEL M; AGUT H;
Indirizzi:
GRP HOSP PITIE SALPETRIERE,CERVI,VIROL LAB,83 BLVD HOP F-75651 PARIS 13 FRANCE CTR HOSP AVICENNE,SERV HEMATOL BIOL BOBIGNY FRANCE CTR HOSP PITIE SALPETRIERE,VIROL LAB PARIS FRANCE CTR HOSP PITIE SALPETRIERE,HEMATOL LAB PARIS FRANCE CTR HOSP PITIE SALPETRIERE,HISTOL LAB PARIS FRANCE CHU ANGERS,ANAT PATHOL LAB ANGERS FRANCE CHR JEAN MINJOZ,ANAT PATHOL LAB BESANCON FRANCE
Titolo Testata:
Journal of medical virology
fascicolo: 3, volume: 53, anno: 1997,
pagine: 277 - 281
SICI:
0146-6615(1997)53:3<277:DRAIVL>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SARCOMA-ASSOCIATED HERPESVIRUS; KAPOSIS-SARCOMA; DNA-SEQUENCES; AIDS; INFECTION; PATIENT;
Keywords:
POSTTRANSPLANT LYMPHOMA; BURKITTS LYMPHOMA; PRIMARY EFFUSION LYMPHOMA; LARGE CELL LYMPHOMA; FOLLICULAR HYPERPLASIA; QUANTITATIVE PCR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
J. Feuillard et al., "DETECTION RATE AND INTRATUMORAL VIRUS LOAD OF HUMAN-HERPESVIRUS-8 IN IMMUNODEFICIENCY-RELATED B-CELL LYMPHOID MALIGNANCIES", Journal of medical virology, 53(3), 1997, pp. 277-281

Abstract

Human herpesvirus-8 (HHV-8), associated with Kaposi's sarcoma, primary effusion lymphoma, and Castleman's disease, has been found in circulating B-cells and might have a causative role in B-cell malignancies associated with immunodeficiency syndromes. We determined the rate of detection and intratumoral virus load of HHV-8 by means of a semiquantitative approach in post-transplant lymphoproliferative diseases (PTLDs), AIDS-related non-Hodgkin's lymphomas (NHLs), including both Burkitt's lymphomas (BLs) and large cell lymphomas (LCLs), as well as in control groups consisting of follicular hyperplasias (FHs) and HIV-negative LCLs. HHV-8 sequences were detected at a similar rate in HIV-negative PTLDs (24%), HIV-negative LCLs (22%) and HIV-negative FHs (17%). Thedetection rate was significantly higher in HIV-positive BLs (73%), HIV-positive LCLs (67%), and HIV-positive FHs (65%) supporting the view of an epidemiological link between HHV-8 and HIV infections. The viralload was 10(2) genome copies per cell in the single case of primary effusion lymphoma included in the LCL group while it was 10(-3) copy per cell (median value; range: 10(-4)-10(-1)) in all the other HHV-8-positive samples. No significant difference of viral load was found according to HIV status. The virus loads of PTLDs and HIV-positive LCLs were significantly higher than those observed in HIV-positive BLs and FHs, suggesting, to some extent, that the degree of immunodeficiency may influence HHV-8 replication. However, with the exception of the singlecase of primary effusion lymphoma studied, the low intratumoral load of HHV-8 strongly argues against a direct causative agent of the virusin the occurrence of PTLDs and AIDS-related NHLs. (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:14:23