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Titolo:
EFFECTS OF A TRAINING-PROGRAM ON RESTING PLASMA 2-HYDROXYCATECHOLESTROGEN LEVELS IN EUMENORRHEIC WOMEN
Autore:
DECREE C; BALL P; SEIDLITZ B; VANKRANENBURG G; GEURTEN P; KEIZER HA;
Indirizzi:
INST GYNECOENDOCRINOL RES,DEPT APPL & EXPT REPROD ENDOCRINOL B-3000 LOUVAIN 3 BELGIUM UNIV LUBECK,DEPT BIOCHEM & CLIN ENDOCRINOL D-23538 LUBECK GERMANY UNIV MAASTRICHT,FAC HLTH SCI,DEPT MOVEMENT SCI NL-6200 MD MAASTRICHT NETHERLANDS
Titolo Testata:
Journal of applied physiology
fascicolo: 5, volume: 83, anno: 1997,
pagine: 1551 - 1556
SICI:
8750-7587(1997)83:5<1551:EOATOR>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXERCISE; ESTRADIOL; CATECHOLAMINES; METABOLISM; PITUITARY; SECRETION; BRAIN; RAT;
Keywords:
AMENORRHEA; ANOVULATION; CATECHOLAMINES; CATECHOL-O-METHYLTRANSFERASE; ESTROGENS; 2-HYDROXYLASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
C. Decree et al., "EFFECTS OF A TRAINING-PROGRAM ON RESTING PLASMA 2-HYDROXYCATECHOLESTROGEN LEVELS IN EUMENORRHEIC WOMEN", Journal of applied physiology, 83(5), 1997, pp. 1551-1556

Abstract

Catecholestrogens (CE) represent a major metabolic pathway in estrogen metabolism. Previous information on CE and training is limited to two cross-sectional studies that did not involve standardized training. Our purpose, by means of a prospective design, was to evaluate the effects of a brief, exhaustive training program on resting plasma concentrations of a-hydroxy CE. The experimental design spanned two menstrualcycles: a control cycle and a training cycle. The subjects were nine previously untrained, eumenorrheic women [body fat: 24.8 +/- 1.0 (SE) %]. Data were collected during the follicular (FPh) and the luteal phases (LPh). Posttraining FPh and LPh tests were held the day after the last day of a 5-day period of training on a cycle ergometer. Total 2-hydroxyestrogens (2-OHE) averaged 200 +/- 29 pg/ml during the FPh and 420 +/- 54 pg/ml during the LPh (P < 0.05). Levels of total 2-methoxyestrogens (2-MeOE) were 237 +/- 32 pg/ml during the FPh and 339 +/- 26 pg/ml during the LPh (P < 0.05). After training, although the plasma levels of 2-OHE significantly decreased (-21%; P < 0.05) during the LPh,the actual CE formation (as estimated from the 2-OHE-to-total estrogens ratio) increased (+29%; P < 0.05). CE activity, as expressed by the2-MeOE-to-2-OHE ratio, showed significantly higher values in both phases (FPh, + 14%; LPh, + 13%; P < 0.05). At the same time, resting levels of norepinephrine (NE) were increased by 42% (P < 0.05). CE strongly inhibit biological decomposition of NE by catechol-O-methyltransferase (COMT). Results of the present study suggest that, in response to training, CE are increasingly competing with the enzyme COMT, thus preventing premature NE deactivation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 15:35:21