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Titolo: AN INVESTIGATION INTO THE EFFECT OF INPUT FUNCTION SHAPE AND IMAGE ACQUISITION INTERVAL ON ESTIMATES OF WASHIN FOR DYNAMIC CARDIAC SPECT
Autore: ROSS SG; WELCH A; GULLBERG GT; HUESMAN RH;
 Indirizzi:
 UNIV UTAH,MED CTR AC213,DEPT RADIOL,MED IMAGING RES LAB SALT LAKE CITY UT 84132 UNIV UTAH,MED CTR AC213,DEPT RADIOL,MED IMAGING RES LAB SALT LAKE CITY UT 84132 UNIV CALIF BERKELEY,LAWRENCE BERKELEY NATL LAB BERKELEY CA 94720
 Titolo Testata:
 Physics in medicine and biology
fascicolo: 11,
volume: 42,
anno: 1997,
pagine: 2193  2213
 SICI:
 00319155(1997)42:11<2193:AIITEO>2.0.ZU;2B
 Fonte:
 ISI
 Lingua:
 ENG
 Soggetto:
 MYOCARDIAL BLOODFLOW; POSITRON EMISSION TOMOGRAPHY; POINT RESPONSE CORRECTION; NOISE PROPERTIES; RECONSTRUCTION ALGORITHMS; KINETICPARAMETERS; EM ALGORITHM; PET; MODEL; IMPLEMENTATION;
 Tipo documento:
 Article
 Natura:
 Periodico
 Settore Disciplinare:
 Science Citation Index Expanded
 Citazioni:
 29
 Recensione:
 Indirizzi per estratti:



 Citazione:
 S.G. Ross et al., "AN INVESTIGATION INTO THE EFFECT OF INPUT FUNCTION SHAPE AND IMAGE ACQUISITION INTERVAL ON ESTIMATES OF WASHIN FOR DYNAMIC CARDIAC SPECT", Physics in medicine and biology, 42(11), 1997, pp. 21932213
Abstract
Dynamic cardiac SPECT and PET can be used to measure myocardial perfusion by estimating the kinetic rate constant describing the washin of radioactivelabelled tracers from the blood to the extravascular myocardial tissue. Because of differences in photon statistics and data acquisition techniques, protocols which produce optimal estimates of the washin for dynamic cardiac PET may give suboptimal estimates if applied in dynamic cardiac SPECT. Two important factors in the estimation ofwashin are the shape of the tracer input function and the image acquisition interval. This study uses computer simulations to investigate the effect of varying the tracer infusion length and image acquisition interval on the bias and variance of estimates of washin obtained withdynamic cardiac SPECT and Tc99mlabelled teboroxime. Bias in parameter estimates can be introduced by aliasing, integration of the timevarying radioactivity by the detector, and detector motion. This bias can be reduced by decreasing the acquisition interval and using a longerduration input function. However, this results in poor photon statistics, which generate large variance, and can also introduce bias in theestimates of the washin. Our studies indicate that better estimates of the washin are obtained by using an acquisition interval that is of sufficient duration to obtain adequate photon statistics even if this is at the expense of temporal resolution. The increase in bias caused by using a 10 or 20 s acquisition interval instead of a 5 s acquisition interval is minimal when compared with the reduction in variance. Variance in estimates is also reduced by using a sharp input function, resulting in higher peak counts during washin. It is also shown that the variance of estimates of the washin increases generally when faster kinetics are observed. This variance can, however, be reduced by usinglonger acquisition intervals.
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Documento generato il 15/07/20 alle ore 04:50:39