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Titolo:
EXPRESSION OF ADHESION MOLECULES IN NONALLERGIC CHRONIC SINUSITIS
Autore:
SHIMOMURA A; IKEDA K; SUZUKI H; NAKABAYASHI S; OSHIMA T; FURUKAWA M; TAKASAKA T; ANDO N; OHTANI H; NAGURA H;
Indirizzi:
TOHOKU UNIV,SCH MED,DEPT OTORHINOLARYNGOL,AOBA KU,1-1 SEIRYOMACHI SENDAI MIYAGI 98077 JAPAN TOHOKU UNIV,SCH MED,DEPT OTORHINOLARYNGOL,AOBA KU SENDAI MIYAGI 98077JAPAN TOHOKU UNIV,SCH MED,DEPT PATHOL,AOBA KU SENDAI MIYAGI 98077 JAPAN
Titolo Testata:
The Laryngoscope
fascicolo: 11, volume: 107, anno: 1997,
parte:, 1
pagine: 1519 - 1524
SICI:
0023-852X(1997)107:11<1519:EOAMIN>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY EPITHELIAL-CELLS; TUMOR NECROSIS FACTOR; ENDOTHELIAL-CELLS; MESSENGER-RNA; NASAL POLYPS; EOSINOPHIL; INTERLEUKIN-1; INFLAMMATION; ACTIVATION; ASTHMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
A. Shimomura et al., "EXPRESSION OF ADHESION MOLECULES IN NONALLERGIC CHRONIC SINUSITIS", The Laryngoscope, 107(11), 1997, pp. 1519-1524

Abstract

Endothelial and epithelial adhesion molecules are important in the recruitment of leukocytes to inflammatory sites. To determine the relationship between recruited leukocytes and adhesion molecules in the paranasal sinus mucosa of nonallergic chronic sinusitis, we surgically obtained mucosa from 16 patients and identified the expression of intercellular adhesion molecules (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin, and P-selectin by immunohistochemistry. Neutrophils were significantly dominant in the nasal discharge as compared with eosinophils, The degree of neutrophil infiltration in the paranasal sinus mucosa was prominent in both intraepithelial and subepithelial areas as compared with the lamina propria, In each tissue site, the degree of infiltration of neutrophils was similar to that of eosinophils. These findings suggest that the tissue neutrophils actively and rapidly migrated into the lumen, All the adhesion molecules except VCAM-1 were expressed in the vascular endothelial cells. On the other hand, the surface epithelial cells showed the expression of only ICAM-1. The expression of ICAM-1 on the endothelial cells correlated with the degree of neutrophil infiltration in the mucosa, The eosinophil infiltration was not dependent on any adhesion molecules examined here. It was concluded that ICAM-1 expression in the mucosa may be involved in neutrophil recruitment and may contribute to the establishment of the inflammatory cell distribution in the paranasal sinus of nonallergic chronicsinusitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 16:14:07