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Titolo:
QUANTIFICATION OF FUROSEMIDE FROM SERUM AND TISSUES USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
Autore:
MILLS CD; WHITWORTH C; RYBAK LP; HENLEY CM;
Indirizzi:
AMGEN INC,MS 51C,1840 DEHAVILLAND DR THOUSAND OAKS CA 91320 SO ILLINOIS UNIV,DEPT SURG SPRINGFIELD IL 62794
Titolo Testata:
Journal of chromatography B. Biomedical sciences and applications
fascicolo: 1, volume: 701, anno: 1997,
pagine: 65 - 70
SICI:
0378-4347(1997)701:1<65:QOFFSA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEARING-LOSS; OTOTOXICITY;
Keywords:
FUROSEMIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
C.D. Mills et al., "QUANTIFICATION OF FUROSEMIDE FROM SERUM AND TISSUES USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY", Journal of chromatography B. Biomedical sciences and applications, 701(1), 1997, pp. 65-70

Abstract

Since pharmacokinetics may play a significant role in furosemide (FSM) developmental ototoxicity, we developed an assay for the extraction and quantification of FSM in tissue and fluid from neonatal and adult rats. Rats from post-natal day (PND) 10, 30 and 50, were given an intravenous dose of FSM (35 mg/kg). Blood and tissues were analyzed by HPLC. FSM in serum, perilymph and liver was elevated in PND ten rats as was the body burden of FSM. Renal concentrations were higher in older rats. Altered clearance of FSM in developing rats may result in higher concentrations in the cochlea and ototoxicity. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 10:28:37