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Titolo:
HIGH-RATE OF INTESTINAL-ABSORPTION OF THE PHOSPHOLIPID ANALOG 1-DODECYL 2-[1-C-14] OCTANAMIDO-SN-2-DEOXY-GLYCERO-3-PHOSPHOCHOLINE IN THE RAT
Autore:
BOUCROT P; BOURASS J; ELKIHEL L; LETOURNEUX Y; GANDEMER G;
Indirizzi:
INRA,LAB ETUD INTERACT MOL ALIMENTAIRES,BP7 1627 F-44316 NANTES 3 FRANCE LAB SYNTH & ETUD SUBST NAT ACTIV BIOL F-17042 LA ROCHELLE 1 FRANCE
Titolo Testata:
Pharmacological research
fascicolo: 2, volume: 36, anno: 1997,
pagine: 135 - 139
SICI:
1043-6618(1997)36:2<135:HOIOTP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARACHIDONIC-ACID RELEASE; PERITONEAL-MACROPHAGES; A(2) INHIBITION;
Keywords:
PHOSPHOLIPID ANALOG; PHOSPHOLIPASE A(2); INTESTINAL ABSORPTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
P. Boucrot et al., "HIGH-RATE OF INTESTINAL-ABSORPTION OF THE PHOSPHOLIPID ANALOG 1-DODECYL 2-[1-C-14] OCTANAMIDO-SN-2-DEOXY-GLYCERO-3-PHOSPHOCHOLINE IN THE RAT", Pharmacological research, 36(2), 1997, pp. 135-139

Abstract

The phospholipid analogue with two short fatty chains, 1-dodecyl-2-[1-C-14] octanamido-sn-2-deoxy-glycero-3-phosphocholine ([C-14] phospholipid analogue), with a non-hydrolyzable bond at position 2 of the glycerol, is an inhibitor of phospholipase A(2). It was obtained after chemical synthesis and 0.5 mu mol was solubilized in Na+ taurocholate with an equimolar amount of 1-octadecanoyl -[H-3]eicosatetraenoyl-sn-glycero-3-phosphocholine which is the current substrate of phospholipases A(2). Both molecules were introduced into the duodenum of rats in order to follow their captations by intestinal mucosa cells for 30, 60 or 90 min. The [C-14] phospholipid analogue was poorly split by phospholipases A(2) (pancreatic juice and intracellular enzymes). It disappeared from the intestinal contents (87% of the dose gone in 90 min) as rapidly as the tritiated lecithin (81%) but this was later split by the phospholipases at a higher rate. (C) 1997 The Italian Pharmacological Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:50:50