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Titolo:
CD34-BLOOD PROGENITOR CELLS AND CAN RETAIN THEIR PROLIFERATIVE POTENTIAL( CELLS CAN BE SELECTED EFFICIENTLY FROM CRYOPRESERVED PERIPHERAL)
Autore:
ALCORN MJ; HOLYOAKE TL; RICHMOND LJ; PEARSON C; FARRELL E; GREEN R; DUNLOP DJ; FRANKLIN IM;
Indirizzi:
GLASGOW ROYAL INFIRM,DEPT HAEMATOL,CASTLE ST GLASGOW G4 0SF LANARK SCOTLAND GLASGOW ROYAL INFIRM,DEPT MED ONCOL GLASGOW G4 0SF LANARK SCOTLAND W SCOTLAND BLOOD TRANSFUS SERV GLASGOW LANARK SCOTLAND
Titolo Testata:
Journal of hematotherapy
fascicolo: 5, volume: 6, anno: 1997,
pagine: 501 - 510
SICI:
1061-6128(1997)6:5<501:CPCACR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTOLOGOUS BONE-MARROW; HEMATOPOIETIC-CELLS; STEM-CELLS; TRANSPLANTATION; INTERLEUKIN-3; ENGRAFTMENT; CONTRIBUTE; MARKING; RELAPSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Alcorn et al., "CD34-BLOOD PROGENITOR CELLS AND CAN RETAIN THEIR PROLIFERATIVE POTENTIAL( CELLS CAN BE SELECTED EFFICIENTLY FROM CRYOPRESERVED PERIPHERAL)", Journal of hematotherapy, 6(5), 1997, pp. 501-510

Abstract

Hematopoietic stem and progenitor cells express the CD34 antigen, Techniques have been developed that enable purified populations of CD34+ cells to be selected from hematopoietic tissues, These selected CD34+ cells have several potential applications, including CD34 selection toobtain a tumor purging effect in autologous transplantation studies and using CD34+ cells as the starting cells for ex vivo expansion studies and as a vehicle for gene transduction protocols, We have investigated the feasibility of using cryopreserved peripheral blood progenitorcells (PBPC) for CD34 selection, Cells could be recovered from cryopreservation with good yields and high viability, After CD34 selection, the final product was, on average, 84% pure, with a recovery of 54%, These cells retained extensive proliferative potential, as demonstratedby ex vivo expansion culture, We believe that cryopreserved PBPC could be thawed, and CD34+ cells could be selected and used for transplantation following high-dose chemotherapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 16:09:39