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Titolo:
MOLECULAR-DETECTION OF A B-CELL CLONE IN A CASE OF PTCL IN THE ABSENCE OF T-CELL CLONALITY
Autore:
SMITH JL; HODGES E; QUIN CT; WRIGHT DH;
Indirizzi:
SOUTHAMPTON UNIV HOSP NHS TRUST,WESSEX IMMUNOL SERV,IMMUNOL GRP,TREMONA RD SOUTHAMPTON SO16 6YD HANTS ENGLAND SOUTHAMPTON UNIV HOSP NHS TRUST,WESSEX IMMUNOL SERV,MOL IMMUNOL GRP SOUTHAMPTON SO16 6YD HANTS ENGLAND SOUTHAMPTON UNIV HOSP NHS TRUST,DEPT PATHOL SOUTHAMPTON SO16 6YD HANTS ENGLAND
Titolo Testata:
Hematological oncology
fascicolo: 2, volume: 15, anno: 1997,
pagine: 63 - 70
SICI:
0278-0232(1997)15:2<63:MOABCI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; EPSTEIN-BARR-VIRUS; ANGIOIMMUNOBLASTIC LYMPHADENOPATHY; LYMPHOPROLIFERATIVE DISORDERS; IMMUNOBLASTIC LYMPHOMA; ANTIGEN RECEPTOR; BETA-CHAIN; REARRANGEMENT; GENES; HETEROGENEITY;
Keywords:
PERIPHERAL T CELL LYMPHOMA; PCR; T CELL RECEPTOR; IMMUNOGLOBULIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Smith et al., "MOLECULAR-DETECTION OF A B-CELL CLONE IN A CASE OF PTCL IN THE ABSENCE OF T-CELL CLONALITY", Hematological oncology, 15(2), 1997, pp. 63-70

Abstract

In this paper we document a case of peripheral T cell lymphoma (PTCL)that exhibited variable T cell histology at presentation and follow-up. Southern blot analysis for T cell receptor (TCR) and immunoglobulin(Ig) receptor gene rearrangements failed to reveal clonal T or B cellpopulations. TCR gamma (TCRG) and beta(TCRB) chain gene polymerase chain reaction (PCR) amplification of DNA isolated from biopsies was also consistent with polyclonal T cell populations, however Ig PCR revealed clonal Ig rearrangements in follow-up biopsies but not in the presentation biopsy. There was no histological evidence for a neoplastic B cell population in these biopsies although occasional EB virus positive blasts were present. The significance of a cryptic B cell clone is unknown but suggests a relationship with the proliferating polyclonal Tcells in this case of PTCL. These data reflect the complexity of PTCLwith implications for treatment and patient management. (C) 1997 JohnWiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 07:29:17