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Titolo:
CIRCANNUAL SOMATOSTATIN GENE AND SOMATOSTATIN RECEPTOR GENE-EXPRESSION IN THE EARLY POSTNATAL RAT PINEAL-GLAND
Autore:
MATO E; SANTISTEBAN P; CHOWEN JA; FORNAS O; BOUWENS M; PUIGDOMINGO M; ARGENTE J; WEBB SM;
Indirizzi:
AUTONOMOUS UNIV BARCELONA,HOSP SANT PAU,DEPT ENDOCRINOL,PARE CLARET 167 E-08025 BARCELONA SPAIN AUTONOMOUS UNIV BARCELONA,HOSP SANT PAU,DEPT ENDOCRINOL E-08025 BARCELONA SPAIN CSIC,LAB NEUROPLASTICIDAD MADRID SPAIN CSIC,INST INVEST BIOMED MADRID SPAIN AUTONOMOUS UNIV MADRID,HOSP NINO JESUS,DEPT PEDIAT MADRID SPAIN
Titolo Testata:
Neuroendocrinology
fascicolo: 5, volume: 66, anno: 1997,
pagine: 368 - 374
SICI:
0028-3835(1997)66:5<368:CSGASR>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOREACTIVE SOMATOSTATIN; PERIVENTRICULAR NUCLEUS; CELL-PROLIFERATION; CIRCADIAN-RHYTHM; HARDERIAN-GLAND; GROWTH; RETINA; VASOPRESSIN; DARKNESS; OXYTOCIN;
Keywords:
SOMATOSTATIN; SOMATOSTATIN RECEPTOR; PINEAL GLAND; RHYTHMS; MOLECULAR NEUROENDOCRINOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
E. Mato et al., "CIRCANNUAL SOMATOSTATIN GENE AND SOMATOSTATIN RECEPTOR GENE-EXPRESSION IN THE EARLY POSTNATAL RAT PINEAL-GLAND", Neuroendocrinology, 66(5), 1997, pp. 368-374

Abstract

The origin of somatostatin in the pineal gland is controversial as a double origin - neural in pinealopetal nerve fibers and parenchymal corresponding to locally synthesized peptide - is suggested. We have investigated the ontogeny and possible circadian and circannual variations of somatostatin and somatostatin receptor gene expression in the ratpineal gland using RT-PCR. Somatostatin gene expression was observed in the pineal of animals up to 15 days of postnatal life in autumn andwinter, but not in prepubertal or adult rats; no transcript was detected during spring and summer at any age and a circadian rhythm was only detected in 15-day-old rats, In situ hybridization confirmed these results. The transcript of the somatostatin receptor gene (SSTR2) was detected at all ages studied with no seasonal variations in its expression, indicating separate regulatory mechanisms. In conclusion, somatostatin and somatostatin receptor mRNAs are expressed in the neonatal rat pineal with circadian and seasonal variations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:15:28