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Titolo:
THE DISCOVERY OF 3 NOVEL HUMAN VIRUSES - HUMAN-HERPESVIRUS-6, HUMAN-HERPESVIRUS-7 AND HUMAN-HERPESVIRUS-8
Autore:
AGUT H; CALVEZ V; FILLET AM; HURAUX JM;
Indirizzi:
GRP HOSP PITIE SALPETRIERE,CERVI,VIROL LAB,83 BD HOP F-75651 PARIS 13FRANCE
Titolo Testata:
Bulletin de l'Academie nationale de medecine
fascicolo: 6, volume: 181, anno: 1997,
pagine: 1009 - 1022
SICI:
0001-4079(1997)181:6<1009:TDO3NH>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
FRE
Soggetto:
SARCOMA-ASSOCIATED HERPESVIRUS; ACQUIRED-IMMUNODEFICIENCY-SYNDROME; KAPOSIS-SARCOMA; DNA-SEQUENCES; MARROW TRANSPLANTATION; EXANTHEM-SUBITUM; HIV-INFECTION; CAUSAL AGENT; AIDS; TISSUE;
Keywords:
HERPESVIRUS 6, HUMAN; HERPESVIRUS 7, HUMAN; HERPESVIRUS, KAPOSIS SARCOMA-ASSOCIATED; T-LYMPHOCYTES; B-LYMPHOCYTES; SARCOMA, KAPOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
H. Agut et al., "THE DISCOVERY OF 3 NOVEL HUMAN VIRUSES - HUMAN-HERPESVIRUS-6, HUMAN-HERPESVIRUS-7 AND HUMAN-HERPESVIRUS-8", Bulletin de l'Academie nationale de medecine, 181(6), 1997, pp. 1009-1022

Abstract

Three novel human herpesviruses have been discovered in the last years: human herpesvirus 6 (HHV-6) in 1986, human herpesvirus 7 (HHV-7) in1990, human herpesvirus 8 (HHV-8) in 1994. HHV-6 and HHV-7 were identified after their isolation from blood lymphoctye cultures, while HHV-8 was first detected by means of a specific molecular biology approachin the search for the etiologic agent of Kaposi's sarcoma. The three viruses infect lymphocytes, T-cells in the case of HHV-6 and HHV-7, B-cells in the case of HHV-8. Human infection with HHV-6 and HHV-7, B-cells in the case of HHV-8. Human infection with HHV-6 and HHV-7 is ubiquitous and widespread while HHV-8 infection seems to be more restricted, at least in Western countries. The propagation in cell culture in vitro can be done easily with HHV-6, with more difficulties in the caseof HHV-7 and has not been completely obtained in the case of HHV-8. The polymerase chain reaction is the common method for the detection ofthese three viruses in human samples. The oncogenic role of HHV-6 andHHV-7 which were both classified in Betaherpesvirinae subfamily has not been convincingly demonstrated. HHV-8, classified as a member of Gammaherpesvirinae subfamily, is strongly associated with three lymphoproliferative diseases: Kaposi's sarcoma, Castleman's disease and primary effusion lymphomas.

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Documento generato il 30/11/20 alle ore 10:13:09