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Titolo:
ASSOCIATION OF MERCURY RESISTANCE WITH ANTIBIOTIC-RESISTANCE IN THE GRAM-NEGATIVE FECAL BACTERIA OF PRIMATES
Autore:
WIREMAN J; LIEBERT CA; SMITH T; SUMMERS AO;
Indirizzi:
UNIV GEORGIA,DEPT MICROBIOL ATHENS GA 30602 UNIV GEORGIA,DEPT MICROBIOL ATHENS GA 30602
Titolo Testata:
Applied and environmental microbiology
fascicolo: 11, volume: 63, anno: 1997,
pagine: 4494 - 4503
SICI:
0099-2240(1997)63:11<4494:AOMRWA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMID-DETERMINED RESISTANCE; DENTAL AMALGAM FILLINGS; PSEUDOMONAS-AERUGINOSA; ORGANOMERCURIAL LYASE; ESCHERICHIA-COLI; DNA-SEQUENCES; GENE; INTEGRONS; TRANSPOSONS; TN21;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
J. Wireman et al., "ASSOCIATION OF MERCURY RESISTANCE WITH ANTIBIOTIC-RESISTANCE IN THE GRAM-NEGATIVE FECAL BACTERIA OF PRIMATES", Applied and environmental microbiology, 63(11), 1997, pp. 4494-4503

Abstract

Gram-negative fecal bacteria from three longitudinal Hg exposure experiments and from two independent survey collections were examined for their carriage of the mercury resistance (mer) locus. The occurrence of antibiotic resistance was also assessed in both mercury-resistant (Hg-r) and mercury-susceptible (Hg-5) isolates from the same collections. The longitudinal studies involved exposure of the intestinal flora to Hg released from amalgam ''silver'' dental restorations in six monkeys. Hg-r strains were recovered before the installation of amalgams, and frequently these became the dominant strains,while amalgams were installed, Such persistent Hg-r strains always carried the same mer locus throughout the experiments. In both the longitudinal and survey collections, certain mer loci were preferentially associated with one genus, whereas other mer loci were recovered from many genera. In general,strains with any mer locus were more likely to be multiresistant thanwere strains without mer loci; this clustering tendency was also seenfor antibiotic resistance genes. However, the association of antibiotic multiresistance with mer loci was not random; regardless of source,certain mer loci occurred in highly multiresistant strains (with as many as seven antibiotic resistances), whereas other mer loci were found in strains without any antibiotic resistance. The majority of highlymultiresistant Hg-r strains also carried genes characteristic of an integron, a novel genetic element which enables the formation of tandemarrays of antibiotic resistance genes. Hg-r strains lacking antibiotic resistance showed no evidence of integron components.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 08:29:56