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Titolo:
ROLE OF ELEVATED CYTOSOLIC CALCIUM IN THE PATHOGENESIS OF COMPLICATIONS IN DIABETES-MELLITUS
Autore:
MASSRY SG; SMOGORZEWSKI M;
Indirizzi:
UNIV SO CALIF,SCH MED,DIV NEPHROL,2025 ZONAL AVE LOS ANGELES CA 90033 UNIV SO CALIF,SCH MED,DEPT MED LOS ANGELES CA 90033
Titolo Testata:
Mineral and electrolyte metabolism
fascicolo: 3-6, volume: 23, anno: 1997,
pagine: 253 - 260
SICI:
0378-0392(1997)23:3-6<253:ROECCI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC-RENAL-FAILURE; PROTEIN-KINASE-C; NA+-K+-ATPASE; ALDOSE REDUCTASE INHIBITION; EXCESS PARATHYROID-HORMONE; PTH-PTHRP RECEPTOR; PHOSPHATE-DEPLETION; BRAIN SYNAPTOSOMES; PANCREATIC-ISLETS; SECONDARY HYPERPARATHYROIDISM;
Keywords:
CELL DYSFUNCTION IN DIABETES; CALCIUM CHANNEL BLOCKERS; POLYMORPHONUCLEAR LEUKOCYTES; MESSENGER-RNA OF HORMONE RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
98
Recensione:
Indirizzi per estratti:
Citazione:
S.G. Massry e M. Smogorzewski, "ROLE OF ELEVATED CYTOSOLIC CALCIUM IN THE PATHOGENESIS OF COMPLICATIONS IN DIABETES-MELLITUS", Mineral and electrolyte metabolism, 23(3-6), 1997, pp. 253-260

Abstract

Both type I and type II diabetes mellitus are associated with derangements in the regulation of intracellular calcium. Hyperglycemia causesan acute rise in cytosolic calcium ([Ca2+](i)) due to increased calcium influx and in certain cells to mobilization of intracellular calcium stores as well. The increase in calcium entry is secondary to the activation of calcium channels inhibitable by verapamil, nifedipine, or amlodipine. The stimulation of these calcium channels is mediated by the activation of G protein(s), leading to stimulation of various cellular pathways. Chronic hyperglycemia is also associated with decreased calcium exit from cells. The combination of increased calcium influx and decreased calcium efflux leads to sustained elevation in basal levels of [Ca2+](i). The latter abnormality may adversely affect cell function. Treatment of diabetic animals with calcium channel blockers normalizes cell [Ca2+](i) and prevents and/or reverses the derangements incellular function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:29:33