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Titolo:
LIFETIME SMOKING EXPOSURE AFFECTS THE ASSOCIATION OF C-REACTIVE PROTEIN WITH CARDIOVASCULAR-DISEASE RISK-FACTORS AND SUBCLINICAL DISEASE INHEALTHY ELDERLY SUBJECTS
Autore:
TRACY RP; PSATY BM; MACY E; BOVILL EG; CUSHMAN M; CORNELL ES; KULLER LH;
Indirizzi:
UNIV VERMONT,DEPT PATHOL & BIOCHEM,AQUATEC BLDG,T205,55A S PK AVE COLCHESTER VT 05446 UNIV VERMONT,DEPT PATHOL COLCHESTER VT 05446 UNIV VERMONT,DEPT PATHOL & MED COLCHESTER VT 05446 UNIV WASHINGTON,DEPT EPIDEMIOL SEATTLE WA 98195 UNIV WASHINGTON,DEPT HLTH SERV SEATTLE WA 98195 UNIV WASHINGTON,DEPT MED SEATTLE WA 98195 UNIV PITTSBURGH,DEPT EPIDEMIOL PITTSBURGH PA 15261 UNIV PITTSBURGH,DEPT MED PITTSBURGH PA 15261
Titolo Testata:
Arteriosclerosis, thrombosis, and vascular biology
fascicolo: 10, volume: 17, anno: 1997,
pagine: 2167 - 2176
SICI:
1079-5642(1997)17:10<2167:LSEATA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKED-IMMUNOSORBENT-ASSAY; CORONARY HEART-DISEASE; PLASMINOGEN-ACTIVATOR INHIBITOR-1; ACUTE MYOCARDIAL-INFARCTION; SERUM AMYLOID-A; BIOLOGICAL VARIATION; CLINICAL-CHEMISTRY; UNSTABLE ANGINA; FACTOR-VIII; P-SELECTIN;
Keywords:
ATHEROSCLEROSIS; THROMBOSIS; FIBRINOLYSIS; INFLAMMATION; ACUTE-PHASE PROTEINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
R.P. Tracy et al., "LIFETIME SMOKING EXPOSURE AFFECTS THE ASSOCIATION OF C-REACTIVE PROTEIN WITH CARDIOVASCULAR-DISEASE RISK-FACTORS AND SUBCLINICAL DISEASE INHEALTHY ELDERLY SUBJECTS", Arteriosclerosis, thrombosis, and vascular biology, 17(10), 1997, pp. 2167-2176

Abstract

Blood levels of C-reactive protein (CRP), a marker of inflammation, are related to cardiovascular disease risk. To determine cross-sectional correlates in the elderly, we measured CRP in 400 men and women older than 65 years and free of clinical cardiovascular disease at baseline as part of the Cardiovascular Health Study. Only 2% of the values were greater than 10 mg/L, the cut-point usually used to identify inflammation. CRP levels appeared tightly regulated, since there were strongbivariate correlations between CRP and the following: inflammation-sensitive proteins such as fibrinogen (r=.52); measures of fibrinolysis such as plasmin-antiplasmin complex (r=.23); pack-years of smoking (r=.30); and body mass index (r=.24; all P values less than or equal to.001). The association with pack-years was independent of the length of time since cessation of smoking. CRP levels were also associated with coagulation factors VIIc, IXc, and Xc; HDL cholesterol (negative) and triglyceride; diabetes status; diuretic use; ECG abnormalities; and level of exercise. Because of effect modification, two multiple linear regression prediction models were developed for CRP, one each for neversmokers and ever smokers. An a priori physiologic model was used to guide these analyses, which disallowed the use of other inflammation-sensitive variables such as fibrinogen. In never smokers, the independent predictors were body mass index (+), diabetes status (+), plasmin-antiplasmin complex (+), and the presence of ECG abnormalities (+); thismodel predicted 15% of the CRP population variance. In ever smokers, the predictors were body mass index (+), plasmin-antiplasmin complex (), pack-years of smoking (+), HDL cholesterol (-), and ankle-arm blood pressure index (-); this model predicted 42% of the population variance. We conclude that levels of CRP in the healthy elderly are tightlyregulated and reflect lifetime exposure to smoking as well as level of obesity, ongoing level of fibrinolysis, diabetes status, and level of subclinical atherothrombotic disease. Moreover, exposure to smoking affects the relation of CRP to these other factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:22:26