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Titolo:
QUANTITATIVE-EVALUATION OF HUMAN PLACENTAL AROMATASE IN ABNORMAL PREGNANCY - ANENCEPHALUS AND HYDATIDIFORM MOLE
Autore:
YAMAMOTO T; INOUE S; KITAWAKI J; HONJO H;
Indirizzi:
KYOTO PREFECTURAL UNIV MED,DEPT OBSTET & GYNECOL,KAMIKYO KU,KAWARAMACHI HIROKOJI KYOTO 602 JAPAN
Titolo Testata:
Journal of steroid biochemistry and molecular biology
fascicolo: 3-6, volume: 61, anno: 1997,
pagine: 219 - 221
SICI:
0960-0760(1997)61:3-6<219:QOHPAI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOCHROME-P-450; ASSAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
T. Yamamoto et al., "QUANTITATIVE-EVALUATION OF HUMAN PLACENTAL AROMATASE IN ABNORMAL PREGNANCY - ANENCEPHALUS AND HYDATIDIFORM MOLE", Journal of steroid biochemistry and molecular biology, 61(3-6), 1997, pp. 219-221

Abstract

To determine why estriol (E-3) levels in the urine and serum are extremely low in pregnancies with anencephalus or hydatidiform mole, both the aromatase activity and the tissue P450arom concentration in solubilized fractions of placental or mole microsomes was measured. The aromatase activity was measured by tritiated water assay and the tissue P450arom concentration was determined by sandwich enzyme-linked immunosorbent assay (ELISA). Consequently, any tissue P450arom concentration was at a lower level than the regression line for that in normal placenta. The aromatase activity also showed a tendency to be lower than that in normal placenta. These results therefore suggest that a decrease of E-3 in these abnormal pregnancies would result mainly in a lower level of tissue P450arom concentration. (C) 1997 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:43:51