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Titolo:
NEPLANOCIN-A, A POTENT INHIBITOR OF S-ADENOSYLHOMOCYSTEINE HYDROLASE,POTENTIATES GRANULOCYTIC DIFFERENTIATION OF ACUTE PROMYELOCYTIC LEUKEMIA-CELLS INDUCED BY ALL-TRANS-RETINOIC ACID
Autore:
NIITSU N; YAMAMOTOYAMAGUCHI Y; KANATANI Y; SHUTO S; MATSUDA A; UMEDA M; HONMA Y;
Indirizzi:
SAITAMA CANC CTR,RES INST,DEPT CHEMOTHERAPY INA SAITAMA 362 JAPAN SAITAMA CANC CTR,RES INST,DEPT CHEMOTHERAPY INA SAITAMA 362 JAPAN TOHO UNIV,SCH MED,DEPT INTERNAL MED 1 TOKYO JAPAN HOKKAIDO UNIV,FAC PHARMACEUT SCI,KITA KU SAPPORO HOKKAIDO 060 JAPAN
Titolo Testata:
Experimental hematology
fascicolo: 12, volume: 25, anno: 1997,
pagine: 1296 - 1303
SICI:
0301-472X(1997)25:12<1296:NAPIOS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; MYELOID-LEUKEMIA; ERYTHROID-DIFFERENTIATION; RAR-ALPHA; INDUCTION; ANALOGS; METHYLATION; EXPRESSION; THERAPY; AGENTS;
Keywords:
NEPLANOCIN A; DIFFERENTIATION; ALL-TRANS RETINOIC ACID; NB4 CELLS; ACUTE PROMYELOCYTIC LEUKEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
N. Niitsu et al., "NEPLANOCIN-A, A POTENT INHIBITOR OF S-ADENOSYLHOMOCYSTEINE HYDROLASE,POTENTIATES GRANULOCYTIC DIFFERENTIATION OF ACUTE PROMYELOCYTIC LEUKEMIA-CELLS INDUCED BY ALL-TRANS-RETINOIC ACID", Experimental hematology, 25(12), 1997, pp. 1296-1303

Abstract

Several neplanocin A analogs were synthesized and their growth-inhibiting and differentiation-inducing activities on myelogenous leukemia cells were examined. An adenosine kinase-ineffective analog of neplanocin A was effective in inducing differentiation, suggesting that phosphorylation of the nucleoside is not essential for inducing the differentiation of leukemia cells. Neplanocin A induced functional and morphological differentiation of HL-60 cells, but did not effectively induce differentiation of NB4, a cell line derived from a leukemia patient with t(15;17). However, these cells have been known to undergo granulocytic differentiation upon treatment with all-trans retinoic acid (ATRA), and are used as a model for differentiation therapy in acute promyelocytic leukemia. Preexposure of NB4 cells to low concentrations of neplanocin A greatly enhanced the ATRA-induced differentiation of the cells, whereas representative antileukemic drugs such as cytosine arabinoside and daunomycin did not enhance this differentiation. A clinical strategy that combines intermittent treatment with neplanocin A analogsand a low dose of ATRA may increase the clinical response and decrease the adverse effects of ATRA.

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Documento generato il 28/11/20 alle ore 04:15:30