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Titolo:
POTENTIAL EFFICACY OF FUMAGILLIN IN INTESTINAL MICROSPORIDIOSIS DUE TO ENTEROCYTOZOON-BIENEUSI IN PATIENTS WITH HIV-INFECTION - RESULTS OF A DRUG SCREENING STUDY
Autore:
MOLINA JM; GOGUEL J; SARFATI C; CHASTANG C; DESPORTESLIVAGE I; MICHIELS JF; MASLO C; KATLAMA C; COTTE L; LEPORT C; RAFFI F; DEROUIN F; MODAI J;
Indirizzi:
HOP ST LOUIS,CLIN MALAD INFECT,1 AVE CLAUDE VELLEFAUX F-75475 PARIS 10 FRANCE HOP PARIS,ASSISTANCE PUBL PARIS FRANCE HOP HOTEL DIEU NICE FRANCE HOP HOTEL DIEU NANTES FRANCE HOP HOTEL DIEU LYON FRANCE
Titolo Testata:
AIDS
fascicolo: 13, volume: 11, anno: 1997,
pagine: 1603 - 1610
SICI:
0269-9370(1997)11:13<1603:PEOFII>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; SEPTATA-INTESTINALIS; ENCEPHALITOZOON-CUNICULI; TOPICAL FUMAGILLIN; N-SP; AIDS; KERATOCONJUNCTIVITIS; ALBENDAZOLE; DIARRHEA; FEATURES;
Keywords:
FUMAGILLIN; INTESTINAL MICROSPORIDIOSIS; ENTEROCYTOZOON BIENEUSI; THROMBOCYTOPENIA; ALBENDAZOLE; PAROMOMYCIN; ATOVAQUONE; METRONIDAZOLE; TREATMENT; HIV;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Molina et al., "POTENTIAL EFFICACY OF FUMAGILLIN IN INTESTINAL MICROSPORIDIOSIS DUE TO ENTEROCYTOZOON-BIENEUSI IN PATIENTS WITH HIV-INFECTION - RESULTS OF A DRUG SCREENING STUDY", AIDS, 11(13), 1997, pp. 1603-1610

Abstract

Objective: Intestinal microsporidiosis due to Enterocytozoon bieneusiis a frequent cause of chronic diarrhoea in patients with HIV infection for which there is no available therapy. This study was designed tosearch for a drug with activity against this organism. Design: Prospective open-labelled Phase II multicentre study. Setting: University hospitals. Patients: Sixty HIV-infected men with intestinal E. bieneusi infection. Interventions: Ten drug regimens were consecutively tested orally for 3 weeks: albendazole plus metronidazole, sulphadiazine pluspyrimethamine, atovaquone, doxycycline plus nifuroxazide, itraconazole, flubendazole, chloroquine, paromomycin, sparfloxacin and fumagillin. Nine evaluable patients per regimen were required, bur each patient could be enrolled up to three times in the study. Outcome measure: Efficacy was assessed primarily by the clearance of E. bieneusi from stools and intestinal biopsies. The safety of each regimen was also assessed. Results: Only purified fumagillin was able to clear E. bieneusi from stools as well as intestinal biopsies, whereas all other regimens failed to show antiparasitic efficacy. However, only four patients received fumagillin because of drug-induced thrombocytopenia. The four patients who received fumagillin remained free of E. bieneusi infection after a mean follow-up of 10 months. Conclusion: Eradication of E. bieneusi from the intestinal tract of patients with HIV infection and persistent immunosuppression is an achievable goal. Our study allowed the identification of oral fumagillin as a potential treatment for intestinal microsporidiosis due to E. bieneusi.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 13:24:58