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Titolo:
INDUCTION OF CYP2D6 IN PREGNANCY
Autore:
WADELIUS M; DARJ E; FRENNE G; RANE A;
Indirizzi:
UNIV UPPSALA HOSP,DEPT CLIN PHARMACOL S-75185 UPPSALA SWEDEN UNIV UPPSALA HOSP,DEPT OBSTET & GYNECOL S-75185 UPPSALA SWEDEN
Titolo Testata:
Clinical pharmacology and therapeutics
fascicolo: 4, volume: 62, anno: 1997,
pagine: 400 - 407
SICI:
0009-9236(1997)62:4<400:IOCIP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOLIZING CYTOCHROME-P450 FORMS; METOPROLOL METABOLISM; POOR METABOLIZERS; FETAL LIVER; DEBRISOQUINE; EXPRESSION; GENE; DEXTROMETHORPHAN; POLYMORPHISM; OXIDATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M. Wadelius et al., "INDUCTION OF CYP2D6 IN PREGNANCY", Clinical pharmacology and therapeutics, 62(4), 1997, pp. 400-407

Abstract

Expression of the drug-metabolizing enzyme cytochrome P4502D6 (CYP2D6) is predominantly under genetic control, and enzyme-inducing drugs have little influence on its activity, We studied the activity of CYP2D6during pregnancy, One hundred forty pregnant women were genotyped forCYP2D6, Seventeen of them (four poor metabolizers, seven heterozygousextensive metabolizers, and sis extensive metabolizers) were phenotyped with dextromethorphan in late pregnancy and 7 to 11 weeks after parturition, During pregnancy the dextromethorphan/dextrorphan metabolic ratio was significantly reduced (p = 0.0015) among homozygous and heterozygous extensive metabolizers, indicating increased CYP2D6 activity,In contrast, poor metabolizers showed an increased metabolic ratio during pregnancy. These results are consistent with previous findings ofa marked increase in metabolism of the CYP2D6 substrate metoprolol during pregnancy, Both studies indicate an increase in CYP2D6 activity during pregnancy, which may be caused by an induction of the CYP2D6 enzyme.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:45:40