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Titolo:
COMPARISON OF THE EFFECTS OF SELECTIVE ENDOTHELIN ETA AND ETB RECEPTOR ANTAGONISTS IN CONGESTIVE-HEART-FAILURE
Autore:
WADA A; TSUTAMOTO T; FUKAI D; OHNISHI M; MAEDA K; HISANAGA T; MAEDA Y; MATSUDA Y; KINOSHITA M;
Indirizzi:
SHIGA UNIV MED SCI,DEPT INTERNAL MED 1 OTSU SHIGA 52021 JAPAN KYOWA HAKKO KOGYO CO LTD,TOKYO RES LABS TOKYO 194 JAPAN
Titolo Testata:
Journal of the American College of Cardiology
fascicolo: 5, volume: 30, anno: 1997,
pagine: 1385 - 1392
SICI:
0735-1097(1997)30:5<1385:COTEOS>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOCONSTRICTOR PEPTIDE; BLOOD-VESSELS; B-RECEPTOR; CELLS; PRESSURE; POTENT; DOGS; RAT; RES-701-1; SECRETION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
A. Wada et al., "COMPARISON OF THE EFFECTS OF SELECTIVE ENDOTHELIN ETA AND ETB RECEPTOR ANTAGONISTS IN CONGESTIVE-HEART-FAILURE", Journal of the American College of Cardiology, 30(5), 1997, pp. 1385-1392

Abstract

Objectives. This study was designed 1) to determine the extent to which endogenous endothelin (ET) affects hemodynamic, hormonal and body fluid balance through ETA and ETB receptors in congestive heart failure(CHF); and 2) to assess the therapeutic benefits and adverse effects of ET receptor antagonists for ETA and ETB on cardiorenal and neurohormonal variables, Background, ET has two receptors, ETS and ETB, both of which are distributed in various tissues and cells, In vascular beds, ETA receptors mediate vasoconstriction, whereas ETB receptors mediate vasorelaxation. However, ETB receptors also exist in smooth muscle and mediate vasoconstriction. Methods, We administered either the ETA receptor antagonist FR139317 (ER [n = 8], 1 and 10 mg/kg body weight) or the ETB receptor antagonist RES-701-1 (RES [n = 8], 0.2 and 1.5 mg/kg) to dogs with CHF induced by rapid ventricular pacing. The effects of both antagonists on cardiorenal and hormonal functions were studied,Results, FR decreased cardiac pressures and the plasma atrial natriuretic peptide (ANP) level and increased cardiac output (CO), Urinary flow rate and urinary sodium excretion increased in association with an increase in the glomerular filtration rate and renal plasma flow (RFP). In contrast, RES increased cardiac pressures and decreased CO, It also decreased the plasma aldosterone level and RPF. Neither antagonist affected plasma nor epinephrine levels, Conclusions. Endogenous ETs increase cardiac pressures and the retention of body fluid through ETA receptors in CHF, The vasodilative action through ETB receptors is overall functionally more important than the constrictive action through ETB receptors, ETs may regulate the secretion of ANP and aldosterone, Our findings suggest that selective ETA receptor antagonists have potential therapeutic benefits affecting both hemodynamic variables and diuresis, whereas ETB receptor antagonists have adverse hemodynamic effects, with the possibility of preventing fluid retention through suppression of aldosterone secretion in dogs with CHF. (C) 1997 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 00:36:24