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Titolo:
INFLUENCE OF CHRONIC DIETARY ETHANOL ON CYTOKINE PRODUCTION BY MURINESPLENOCYTES AND THYMOCYTES
Autore:
WANG YJ; HUANG DS; GIGER PT; WATSON RR;
Indirizzi:
UNIV ARIZONA,DEPT FAMILY & COMMUNITY MED TUCSON AZ 85721 UNIV ARIZONA,DEPT FAMILY & COMMUNITY MED TUCSON AZ 85721 UNIV ARIZONA,NUTR SCI PROGRAM TUCSON AZ 85721 UNIV ARIZONA,ALCOHOL RES CTR TUCSON AZ 00000 UNIV ARIZONA,DEPT MICROBIOL & IMMUNOL TUCSON AZ 85721 UNIV ARIZONA,DEPT MOLEC & CELLULAR BIOL TUCSON AZ 85721
Titolo Testata:
Alcoholism, clinical and experimental research
fascicolo: 1, volume: 18, anno: 1994,
pagine: 64 - 70
SICI:
0145-6008(1994)18:1<64:IOCDEO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
KILLER-CELL-ACTIVITY; SUPEROXIDE PRODUCTION; IMMUNE REGULATION; LIVER-DISEASE; B-CELLS; ALCOHOL; INTERLEUKIN-4; THYMUS; RAT; CONSUMPTION;
Keywords:
ETHANOL; CYTOKINES; T-CELL MATURATION; IMMUNOMODULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
Y.J. Wang et al., "INFLUENCE OF CHRONIC DIETARY ETHANOL ON CYTOKINE PRODUCTION BY MURINESPLENOCYTES AND THYMOCYTES", Alcoholism, clinical and experimental research, 18(1), 1994, pp. 64-70

Abstract

Prolonged consumption of ethanol (ETOH) results in alterations of host defense via immune modulation, increasing susceptibility to infection. In the present study, effects of chronic dietary ETOH on cytokine production by splenocytes and thymocytes, splenocyte and thymocyte proliferation induced by mitogens, splenic natural killer cell activity, and antibody production (IgA and IgG) were examined. C57BL/6 mice were fed 5% ETOH v/v in the Lieber-DeCarli liquid diet for 11 weeks. Release of interleukin (IL)-2, IL-5, IL-6, IL-10, and interferon (IFN)gamma produced by concanavalin A (Con A) stimulated splenocytes was significantly decreased, whereas secretion of IL-4 was slightly decreased by chronic dietary ETCH compared with controls. Production of tumor necrosis factor-alpha and IL-6 by lipopolysaccharide-stimulated splenocytes was significantly and slightly decreased by ETOH compared with controls, respectively. Splenocyte and thymocyte proliferation induced by ConA was significantly inhibited by ETCH, whereas splenocyte proliferation induced by lipopolysaccharide was not affected. Natural killer cellactivity was significantly inhibited by ETOH compared with controls. The production of IgA and IgG by splenocytes were also significantly decreased by ETCH compared with controls. The levels of IL-2, IL-4, andIL-6 produced by Con A-stimulated thymocytes were significantly reduced by dietary ETOH compared with control, whereas production of IFN-gamma by thymocytes was not affected. Our results suggest that chronic dietary ETOH alters the cytokine release, thereby impairing immune response and T-cell maturation, which increase host susceptibility to infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:24:49