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Titolo:
MODIFICATION OF LYMPHOCYTE SUBSETS IN THE INTESTINAL-ASSOCIATED IMMUNE-SYSTEM AND THYMUS BY CHRONIC ETHANOL-CONSUMPTION
Autore:
LOPEZ MC; HUANG DS; BORGS P; WANG YJ; WATSON RR;
Indirizzi:
UNIV ARIZONA,ARIZONA HLTH SCI CTR,DEPT FAMILY & COMMUNITY MED TUCSON AZ 85724 UNIV ARIZONA,ARIZONA HLTH SCI CTR,DEPT FAMILY & COMMUNITY MED TUCSON AZ 85724 UNIV ARIZONA,ARIZONA CANC CTR,NIAAA ALCOHOL RES CTR TUCSON AZ 85724 UNIV ARIZONA,ARIZONA HLTH SCI CTR,DEPT MICROBIOL & IMMUNOL TUCSON AZ 85724 UNIV ARIZONA,ARIZONA HLTH SCI CTR,DEPT SURG TUCSON AZ 85724
Titolo Testata:
Alcoholism, clinical and experimental research
fascicolo: 1, volume: 18, anno: 1994,
pagine: 8 - 11
SICI:
0145-6008(1994)18:1<8:MOLSIT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CD4+ T-CELLS; FUNCTIONAL-HETEROGENEITY; DIFFERENTIAL EXPRESSION; MICE;
Keywords:
ETHANOL; MUCOSAL IMMUNE SYSTEM; THYMUS; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
M.C. Lopez et al., "MODIFICATION OF LYMPHOCYTE SUBSETS IN THE INTESTINAL-ASSOCIATED IMMUNE-SYSTEM AND THYMUS BY CHRONIC ETHANOL-CONSUMPTION", Alcoholism, clinical and experimental research, 18(1), 1994, pp. 8-11

Abstract

Modification of the mucosa-associated intestinal immune system of female C57BL/6 mice was studied during consumption of the Lieber-DeCarli diet supplemented with 5% v/v ethanol or laboratory chow with ethanol (20% w/v) in the drinking water. All groups received ethanol for 11 weeks. Mice fed the Lieber-DeCarli diet had fewer CD8(+) cells/villus than the chow-fed controls. Mice that received ethanol in the drinking water had fewer Iga-containing cells and CD8(+) cells than controls. There were no differences in the number of cells in the mesenteric lymphnodes between ethanol-treated mice and their respective controls. Nevertheless, chow-fed control mice had more cells than those fed the Lieber-DeCarli control diet. Although no differences were detected in thepercentages of CD4(+), CD8(+), LECAM-1(+), and LECAM-1(+) CD4(+) cells, there was a decrease in the percentage of LECAM-1(+) CD8(+) cells in ethanol-fed mice when compared with their Lieber-DeCarli controls. Mice receiving ethanol in the drinking water showed alterations in the CD4 CD45RC subsets and in the CD8 CD45RC subsets. Similar results wereobserved in mice receiving Lieber-DeCarli diets alone or supplementedwith ethanol. The low dose, chronic exposure of dietary ethanol in the Lieber-DeCarli-fed mice did not significantly affect the numbers of various thymocyte subsets. But, a decrease in the percentage of CD4(-)CD8(+) cells was observed in the thymus of mice receiving ethanol in the drinking water. Chronic ethanol consumption caused significant decreases in the number of CD8(+) and IgA(+) cells in the intestinal lamina propria, important in mucosal immune defenses.

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Documento generato il 01/12/20 alle ore 13:26:17