Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
IMMUNOHISTOCHEMICAL DETECTION OF NITROTYROSINE IN POSTISCHEMIC CEREBRAL-CORTEX IN GERBIL
Autore:
TANAKA K; SHIRAI T; NAGATA E; DEMBO T; FUKUUCHI Y;
Indirizzi:
KEIO UNIV,SCH MED,DEPT NEUROL,SHINJUKU KU,35 SHINANOMACHI TOKYO 160 JAPAN
Titolo Testata:
Neuroscience letters
fascicolo: 1-2, volume: 235, anno: 1997,
pagine: 85 - 88
SICI:
0304-3940(1997)235:1-2<85:IDONIP>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; TYROSINE NITRATION; OXYGEN RADICALS; BRAIN; ISCHEMIA; SUPEROXIDE; RAT;
Keywords:
PEROXYNITRITE; NITROTYROSINE; NITRIC OXIDE; CEREBRAL ISCHEMIA; REPERFUSION INJURY; IMMUNOHISTOCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
K. Tanaka et al., "IMMUNOHISTOCHEMICAL DETECTION OF NITROTYROSINE IN POSTISCHEMIC CEREBRAL-CORTEX IN GERBIL", Neuroscience letters, 235(1-2), 1997, pp. 85-88

Abstract

We examined whether or not nitration of tyrosine residues takes placein the ischemic and postischemic reperfused brain. The nitration of tyrosine residues to produce nitrotyrosine is a sensitive marker elicited by peroxynitrite, a powerful oxidant formed by the reaction of nitric oxide (NO) with superoxide. Mongolian gerbils were subjected to 60 min ischemia induced by occlusion of the right common carotid artery (ischemia group), to 30 min recirculation following 60 min ischemia (reperfusion group) or to sham surgery (sham group). Immunohistochemical staining with polyclonal anti-nitrotyrosine antibody revealed the widespread and distinct occurrence of nitrotyrosine in cortical neurons onthe reperfused side of the brain in the reperfusion group, while onlypartial or weak immunoreactivity was noted on the contralateral side. On the other hand, nitrotyrosine was not detected in the brain of theischemia and sham groups. These findings suggest that nitration of tyrosine residues in various proteins may be closely associated with reperfusion injury of the brain. (C) 1997 Elsevier Science ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 04:41:22