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Titolo:
A NEUTRAL N-METHYLTRANSFERASE ACTIVITY IN THE STRIATUM DETERMINES THELEVEL OF AN ENDOGENOUS MPP-LIKE NEUROTOXIN, 1,2-DIMETHYL-6,7-DIHYDROXYISOQUINOLINIUM ION, IN THE SUBSTANTIA-NIGRA OF HUMAN BRAINS()
Autore:
NAOI M; MARUYAMA W; MATSUBARA K; HASHIZUME Y;
Indirizzi:
NAGOYA INST TECHNOL,DEPT BIOSCI,GOKISO CHO NAGOYA AICHI 466 JAPAN NATL INST LONGEV SCI,DEPT BASIC GERONTOL,BIOCHEM & METAB LAB OBU 474 JAPAN ASAHIKAWA MED COLL,DEPT PHARM ASAHIKAWA HOKKAIDO 078 JAPAN AICHI MED UNIV,INST MED SCI AGING NAGAKUTE AICHI 48011 JAPAN
Titolo Testata:
Neuroscience letters
fascicolo: 1-2, volume: 235, anno: 1997,
pagine: 81 - 84
SICI:
0304-3940(1997)235:1-2<81:ANNAIT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINERGIC NEUROTOXIN; METHYLATION; RAT; N-METHYL(R)SALSOLINOL; PYRIDINES; PRECURSOR;
Keywords:
PARKINSONS DISEASE; NEUROTOXIN; N-METHYLTRANSFERASE; N-METHY[(R)SALSOLINOL; 1,2-DIMETHYL-6,7-DIHYDROXYISOQUINOLINIUM ION; DOPAMINE; NIGRO-STRIATUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
M. Naoi et al., "A NEUTRAL N-METHYLTRANSFERASE ACTIVITY IN THE STRIATUM DETERMINES THELEVEL OF AN ENDOGENOUS MPP-LIKE NEUROTOXIN, 1,2-DIMETHYL-6,7-DIHYDROXYISOQUINOLINIUM ION, IN THE SUBSTANTIA-NIGRA OF HUMAN BRAINS()", Neuroscience letters, 235(1-2), 1997, pp. 81-84

Abstract

An endogenous MPTP-like dopaminergic neurotoxin, N-methyl(R)salsolinol, increases in the parkinsonian cerebrospinal fluid and accumulates in the human nigro-striatum. An N-methyltransferase specific for (R)salsolinol was found in human brain with optimal pH at 7.0 and 8.5. The correlation of the enzyme activity with the level of N-methyl(R)salsolinol and its oxidation product, 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion was examined in the brain regions. Neutral N-methyltransferase activity in the striatum was found to correlate with the level of the endogenous MPP+-like isoquinolinium ion in the substantia nigra (P < 0.001). Considering that this neutral N-methyltransferase activity increases in parkinsonian lymphocytes, the enzyme may be an endogenous factor in the pathogenesis of Parkinson's disease. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 01:55:03