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Titolo:
PARTIAL OBSTRUCTION OF THE RAT URINARY-BLADDER - EFFECTS ON MITOCHONDRIA AND MITOCHONDRIAL GLUCOSE-METABOLISM IN DETRUSOR SMOOTH-MUSCLE CELLS
Autore:
DAMASER MS; HAUGAARD N; UVELIUS B;
Indirizzi:
UNIV LUND HOSP,DEPT UROL S-22185 LUND SWEDEN UNIV PENN,SCH MED,DIV UROL PHILADELPHIA PA 19104
Titolo Testata:
Neurourol. urodyn.
fascicolo: 6, volume: 16, anno: 1997,
pagine: 601 - 607
SICI:
0733-2467(1997)16:6<601:POOTRU>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFRAVESICAL OUTFLOW OBSTRUCTION; OUTLET OBSTRUCTION; RABBIT DETRUSOR; DEHYDROGENASE;
Keywords:
URINARY BLADDER; OUTLET OBSTRUCTION; MITOCHONDRIA; METABOLISM; OXIDATIVE PHOSPHORYLATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Damaser et al., "PARTIAL OBSTRUCTION OF THE RAT URINARY-BLADDER - EFFECTS ON MITOCHONDRIA AND MITOCHONDRIAL GLUCOSE-METABOLISM IN DETRUSOR SMOOTH-MUSCLE CELLS", Neurourol. urodyn., 16(6), 1997, pp. 601-607

Abstract

The aim of the present study was to measure mitochondrial function inthe obstructed rat bladder, which does not seem to have impaired contractility in vivo. The animals were unoperated control rats and rats with a 12-day partial urinary outlet obstruction. The obstruction increased bladder weight 3-fold. The relative volume (3.5%) in the detrusorsmooth muscle cells composed of mitochondria was unaffected by obstruction. Obstruction did not affect malate dehydrogenase and citrate synthase activity when expressed relative to unit bladder weight. There was, however, a significant decrease in enzyme activity when expressed relative to protein content. This was due to an increased relative protein content in the obstructed bladders. Total enzyme activities per bladder were increased. Oxygen consumption rates in maximally activatedintact control and obstructed preparations in other studies corresponded to a citrate synthase (rate-limiting enzyme) activity only 10% of the maximal enzyme activity found in the present study. We conclude that there is a considerable safety margin in mitochondrial function in intact rat detrusor muscle cells, and that detrusor smooth muscle cells can hypertrophy without any impaired mitochondrial function. (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:39:31