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Titolo:
POTENTIAL AND LIMITATIONS OF TC-99M SESTAMIBI SCINTIGRAPHY FOR THE DIAGNOSIS OF MYOCARDIAL VIABILITY
Autore:
CORNEL JH; ARNESE M; FORSTER T; POSTMATJOA J; REIJS AEM; FIORETTI PM;
Indirizzi:
ACAD ZIEKENHUIS ROTTERDAM,THORAXCTR,BA 300,DR MOLEWATERPL 40 3015 GD ROTTERDAM NETHERLANDS UNIV HOSP ROTTERDAM DIJKZIGT,THORAXCTR ROTTERDAM NETHERLANDS UNIV HOSP ROTTERDAM DIJKZIGT,DEPT NUCL MED ROTTERDAM NETHERLANDS ERASMUS UNIV ROTTERDAM 3000 DR ROTTERDAM NETHERLANDS
Titolo Testata:
Herz
fascicolo: 1, volume: 19, anno: 1994,
pagine: 19 - 27
SICI:
0340-9937(1994)19:1<19:PALOTS>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; VIABLE MYOCARDIUM; THROMBOLYTIC THERAPY; INFARCTION; ISONITRILE; TL-201; TECHNETIUM-99M-SESTAMIBI; TC-99M-SESTAMIBI; ECHOCARDIOGRAPHY; IDENTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
J.H. Cornel et al., "POTENTIAL AND LIMITATIONS OF TC-99M SESTAMIBI SCINTIGRAPHY FOR THE DIAGNOSIS OF MYOCARDIAL VIABILITY", Herz, 19(1), 1994, pp. 19-27

Abstract

Sestamibi is a Tc labeled radiotracer particularly suitable for myocardial perfusion studies, providing similar information as thallium scintigraphy for the diagnosis of coronary artery disease. In comparison with thallium, sestamibi has the advantage of improved imaging properties due to its higher gamma emission. This is particularly relevant when SPECT imaging is considered. The myocardial uptake of sestamibi is partially passively, related to the myocardial flow, and is also related to the metabolic cellular activity, as it is proportional to the electrochemical gradient generated at cell membrane level. While the role for sestamibi in diagnosing coronary artery disease is well accepted, it is still controversial for the assessment of myocardial viability. Clinical studies reported by others and results from our own institution will be described both in the setting of a recent myocardial infarction (myocardial stunning) and of long-standing left ventricular dysfunction (hibernating myocardium). The results concordantly suggest that sestamibi underestimates myocardial viability, compared to the accepted standards of thallium (rest-redistribution or stress-reinjection protocols), 18-F FDG PET and also in the prediction of left ventricular functional recovery after revascularisation. However, the data available at present arye very limited, particularly after revascularisation. Furthermore, according to new promising results, the role of sestamibi in the setting of myocardial viability has potential for improvement, if the injection at rest will be performed during nitrates. It is also foreseen that the combined use of sestamibi perfusion/wall motionscan (first pass and/or gated perfusion studies) and the development of new softwares for attenuation correction might improve the results in the setting of myocardial viability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:37:58