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Titolo:
GENESIS OF MEG SIGNALS IN A MAMMALIAN CNS STRUCTURE
Autore:
OKADA YC; WU J; KYUHOU S;
Indirizzi:
VET ADM MED CTR,MAGNETOPHYSIOL LAB,MEG UNIT 101,2100 RIDGECREST DR SEALBUQUERQUE NM 87108 UNIV NEW MEXICO,SCH MED,DEPT NEUROL ALBUQUERQUE NM 87131 UNIV NEW MEXICO,SCH MED,DEPT PHYSIOL ALBUQUERQUE NM 87131 KANSAI MED UNIV,DEPT PHYSIOL MORIGUCHI OSAKA 570 JAPAN
Titolo Testata:
Electroencephalography and clinical neurophysiology
fascicolo: 4, volume: 103, anno: 1997,
pagine: 474 - 485
SICI:
0013-4694(1997)103:4<474:GOMSIA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CURRENT-SOURCE-DENSITY; MAGNETIC EVOKED FIELD; GUINEA-PIG; HIPPOCAMPUS; CEREBELLUM; NEURONS;
Keywords:
CA1; CA3; HIPPOCAMPUS; MAGNETOENCEPHALOGRAPHY (MEG); ELECTROENCEPHALOGRAPHY (EEG); BIOMAGNETISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
Y.C. Okada et al., "GENESIS OF MEG SIGNALS IN A MAMMALIAN CNS STRUCTURE", Electroencephalography and clinical neurophysiology, 103(4), 1997, pp. 474-485

Abstract

Neuromagnetic signals of guinea pig hippocampal slices were characterized and compared with the extracellular field potential to elucidate the genesis of magnetoencephalographic signals in a mammalian CNS structure. The spatial distribution of magnetic evoked field (MEF) directed normal to bath surface was similar for transverse CA1, longitudinal CA1 and longitudinal CA3 slices in the presence of 0.1 mM picrotoxin (PTX) which blocks inhibitory synaptic transmission; Their MEFs were produced by currents along the longitudinal axis of the pyramidal cells. Comparisons of the MEF with the laminar potential profile revealed that the MEF was generated by intracellular longitudinal currents. The dipolar component of the intracellular currents was the dominant factorgenerating the MEF even at a distance of 2 mm from the slice. The MEFfrom a slice in Ringer's solution without PTX became similar in temporal waveform with time to the MEF in the presence of PTX, indicating the predominance of excitatory connections in generating the MEF and the existence of highly synchronous population activities across the slice even in PTX-free Ringer's solution. The presence of such highly synchronous population activities underlying the MEFs was verified directly with field potentials recorded across the slice. A systematic Variation of the stimulation site revealed a characteristic waveform for each site. The variation of the waveform with stimulation site suggestedthe contribution of many factors, both synaptic and voltage-sensitiveconductances, to the overall waveform of the MEF. (C) 1997 Elsevier Science Ireland Ltd.

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Documento generato il 01/04/20 alle ore 01:23:52