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Titolo:
CAFFEINE MIMICS THE EFFECT OF A DOPAMINE D-2 3 RECEPTOR AGONIST ON THE EXPRESSION OF IMMEDIATE-EARLY GENES IN GLOBUS-PALLIDUS/
Autore:
SVENNINGSSON P; FREDHOLM BB;
Indirizzi:
KAROLINSKA INST,DEPT PHYSIOL & PHARMACOL,SECT MOL NEUROPHARMACOL S-17177 STOCKHOLM SWEDEN
Titolo Testata:
Neuropharmacology
fascicolo: 9, volume: 36, anno: 1997,
pagine: 1309 - 1317
SICI:
0028-3908(1997)36:9<1309:CMTEOA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
A1 ADENOSINE RECEPTOR; RAT STRIATAL NEURONS; MESSENGER-RNA LEVELS; C-FOS EXPRESSION; MOLECULAR-CLONING; BASAL GANGLIA; AUTORADIOGRAPHIC LOCALIZATION; DEPLETED STRIATUM; EVOKED DOPAMINE; NERVOUS-SYSTEM;
Keywords:
CAFFEINE; ADENOSINE A(2A) RECEPTORS; GLOBUS PALLIDUS; IN SITU HYBRIDIZATION; C-FOS; IMMEDIATE EARLY GENES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
64
Recensione:
Indirizzi per estratti:
Citazione:
P. Svenningsson e B.B. Fredholm, "CAFFEINE MIMICS THE EFFECT OF A DOPAMINE D-2 3 RECEPTOR AGONIST ON THE EXPRESSION OF IMMEDIATE-EARLY GENES IN GLOBUS-PALLIDUS/", Neuropharmacology, 36(9), 1997, pp. 1309-1317

Abstract

In order to evaluate the effect of caffeine on striatopallidal neurons we used in situ hybridization to examine the mRNA expression of the immediate early genes (IEGs), c-fos, fos B, c-jun, jun B, NGFI-A and NGFI-B in globus pallidus in rats given single or repeated administration of caffeine. A significant induction of c-fos mRNA, but not of any of the other IEGs, was found 2, 4 and 8 hr after a single injection of50 mg/kg caffeine. Following repeated injections of caffeine for 2 weeks a single challenge with caffeine did not induce the expression of any of the studied genes. The ability of caffeine to increase pallidalc-fos mRNA expression was mimicked by the dopamine D-2/3 receptor agonist quinpirole (1 or 3 mg/kg), whereas the dopamine D-2/3 receptor antagonist raclopride (2 mg/kg) was ineffective. Caffeine and quinpiroledid not have synergistic effects when given together. The caffeine-induced c-fos mRNA expression was not counteracted by concomitant treatment with raclopride. The present data provide evidence that acute treatment with caffeine reduces the activity of the striatopallidal neuron, and since this neuron is inhibitory the result is an increased activity in globus pallidus. The effect of blocking the striatal A(2A) receptors with caffeine is essentially identical to that observed after activation of dopamine D-2 receptors, but is independent of these receptors. The fact that pallidal c-fos mRNA expression decreased upon repeated administration of caffeine may be related to the development of tolerance to locomotion stimulation that occurs following chronic caffeine ingestion. (C) 1997 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 14:16:26