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Titolo:
MODULATED LOW-INTENSITY EHF EMR ACTIVATES OR INHIBITS NEUTROPHIL RESPIRATORY BURST DEPENDING ON MODULATION FREQUENCY
Autore:
GAPEYEV AB; YAKUSHINA VS; CHEMERIS NK; FESENKO EE;
Indirizzi:
RUSSIAN ACAD SCI,INST CELL BIOPHYS PUSHCHINO 142292 MOSCOW REGION RUSSIA LN TOLSTOY TULA STATE PEDAGOG UNIV TULA RUSSIA
Titolo Testata:
Biofizika
fascicolo: 5, volume: 42, anno: 1997,
pagine: 1125 - 1134
SICI:
0006-3029(1997)42:5<1125:MLEEAO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
RUS
Soggetto:
CELLS; FIELD; IRRADIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
A.B. Gapeyev et al., "MODULATED LOW-INTENSITY EHF EMR ACTIVATES OR INHIBITS NEUTROPHIL RESPIRATORY BURST DEPENDING ON MODULATION FREQUENCY", Biofizika, 42(5), 1997, pp. 1125-1134

Abstract

The influence of low-intensity modulated electromagnetic radiation ofextremely high frequencies (EHF EMR) on synergistic reaction of calcium ionophore A23187 and phorbol ester PMA in activation of the respiratory burst of the peritoneal neutrophils of mice line NMRI was investigated. The production of reactive oxygen species by the neutrophils was estimated by luminol-dependent chemiluminescence technique. The cells were irradiated in the Tar field zone of the channel radiator for 20min in the presence of A23187 and then were activated by PMA after switching off the irradiation. It was shown, that continuous EHF EMR (50mu W/cm(2)) inhibited quasi-resonantly the synergistic reaction. The maximum effect was about 25% at carrier frequency of 41,95 GHz. Modulated radiation with carrier frequency of 41,95 GHz and modulation frequency of 1 Hz activated the synergistic reaction, but at modulation frequencies of 0,1, 16 and 50 Hz inhibited one. At fixed modulation frequency of 1 Hz the nonlinear dependence of the effect on the carrier frequency was found. The synergistic reaction was activated in the frequency range of 41,95-42,05 GHz and was inhibited at the frequencies of 41,8-41,9 GHz. The effect was observed only at raised intracellular free calcium concentration and at calcium fluxes through plasma membrane. The obtained results prove the possibility of control over cell functioning by low-intensity modulated EHF EMR, presumably, manipulating byconnected systems of enzyme reactions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:34:25